The Epigenome constitutes the ortography and grammar of the cell abecedary, the Genome. From DNA methylation to histone modifications, from chromatin remodelling to noncoding RNAs, all these chemical marks and molecules facilitate the correct reading of our genetic material. The epigenetic setting sits between the genotype and the phenotype to originate cellular homeostasis. In addition, the plastic and dynamic nature of the epigenetic marks permits the adaptation of tissues, organs, and individuals to changes in the environment. The described belts of DNA, RNA, and protein regulation become almost unrecognizable in many human diseases, with cancer cells being the most studied pathology. There is margin for hope and, due to the reversible nature of the described chemical modifcations, targeting of the proteins that write, erase, and read the epigenetic language have extremely great potential as therapeutic tools. The use of the so-called epigenetic drugs have changed the morbidity of diseases with unmet medical needs, such as myelodisplastic syndrome or cutaneous limphoma. But beyond DNA demethylating agents and inhibitors of histone deacetylases, we have today an expanding portfolio of compounds that target the epigenetic machinery, including histone methyltransferase, histone demethylase, histone kinase, and bromodomain inhibitors. Some of these are central in ongoing clinical trials and high expectations are placed on them, particularly in the context of hematological malignancies and soft tissue tumors. However, other human disorders can follow this lead, and neurodegenerative and cardiovascular disease could eventually benefit from the results obtained in the oncology field. More importantly, additional effects beyond those classically ascribed to these drugs are now beginning to be reported,Citation1,2 some of them related to shifts in the immune recognition systems and the response to agents in the renewed area of immunotherapy. I am sure that we will witness many unexpected advances in now forgotten areas in the same way.
Herein, we have devoted a Special Focus Issue of Epigenetics to Epigenetic Drugs, touching the intimate mechanisms of their effects,Citation3 the irruption of bromodomain inhibitors,Citation4 the next generation of lysine demethylase inhibitors,Citation5 the applications in pediatric brain tumorsCitation6 and follicular lymphoma,Citation7 and their potential uses beyond oncology.Citation8 I hope that all of you enjoy reading these insightful review articles.
Disclosure of potential conflicts of interest
No potential conflicts of interest were disclosed.
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