CONTENTS
Articles
The association between pre-transfusion hemoglobin levels and thalassemia complications
Wasuwit Wanchaitanawong, Adisak Tantiworawit, Pokpong Piriyakhuntorn, Thanawat Rattanathammethee, Sasinee Hantrakool, Chatree Chai-Adisaksopha, Ekarat Rattarittamrong, Lalita Norasetthada, Piangrawee Niprapan, Kanda Fanhchaksai and Pimlak Charoenkwan 1
Prognostic value of RASD1 transcript levels in adult Philadelphia-negative B-cell acute lymphoblastic leukemia
Run-Qing Lu, Li-Xin Wu, Jing Zhang, Ya-Zhen Qin, Yan-Rong Liu, Yue-Yun Lai, Hao Jiang, Ying-Jun Chang, Guo-Rui Ruan and Xiao-Jun Huang 9
Up-regulated miR-155 is associated with poor prognosis in childhood acute lymphoblastic leukemia and promotes cell proliferation targeting ZNF238
Cong Liang, Yu Li, Li-Na Wang, Xiao-Li Zhang, Jie-Si Luo, Chun-Jin Peng, Wen-Yan Tang, Li-Bin Huang, Yan-Lai Tang and Xue-Qun Luo 16
Rapid Communication
Pretreatment grade 4 thrombocytopenia is an independent prognostic factor in adult acute lymphoblastic leukemia: an extended analysis of a single-center retrospective study
Karan Srisurapanont, Wimuthtisuk Prakalapakorn, Chotsurat Sutamworarot, Teerach Siriraksa, Metapon Jinapeng and Thanawat Rattanathammethee 26
Articles
Efficacy and safety of eltrombopag in the treatment of Chinese children with chronic immune thrombocytopenia
Mo Chen, Jian-Pei Fang, Chuan-Xin Zhou, Xin-Yu Li, Shao-Fen Lin and Lu-Hong Xu 31
Decreased bone marrow regulatory innate lymphoid cells show a distinctive miRNA profiling in aplastic anemia
Yingmei Li, Dingming Wan, Rong Guo, Fang Wang, Lijie Han, Danfeng Zhang, Haizhou Xing, Weijie Cao, Yu Liu, Xinsheng Xie, Jifeng Yu and Zhongxing Jiang 37
Long non-coding RNA MALAT1 modulate cell migration, proliferation and apoptosis by sponging microRNA-146a to regulate CXCR4 expression in acute myeloid leukemia
Xian-Fu Sheng, Li-Li Hong, Hui Li, Fei-Yan Huang, Qiang Wen and Hai-Feng Zhuang 43
Case Report
An aberrant F8 intron 1 inversion with concomitant large duplication and deletion in a Chinese severe hemophilia A patient
Xiong Wang, Hongmei Wang, Haowen Tan, Xiu-Ping Liu and Huijun Li 53
Articles
Analysis of gamma-glutamyltransferase in acute promyelocytic leukemia patients undergoing arsenic trioxide treatment
Meijuan Sui, Hong Wei, Qian Zhang, Ruolin Xiu, Xiaohan Shen, Zhuo Zhang and Jin Zhou 58
Comparison of autologous and allogeneic stem cell transplantation for patients with Philadelphia chromosome-positive acute lymphoblastic leukemia
Mengnan Lyu, Erlie Jiang, Yi He, Donglin Yang, Qiaoling Ma, Aiming Pang, Weihua Zhai, Jialin Wei, Yong Huang, Guixin Zhang, Rongli Zhang, Sizhou Feng and Mingzhe Han 65
A five-year retrospective study of treatment outcomes using the L-asparaginase-based regimen as a first-line chemotherapy protocol for patients diagnosed with extranodal NK/T-cell lymphoma, nasal-type, in Thailand
Pongthep Vittayawacharin and Archrob Khuhapinant 75
Assessment of Lebanese healthcare professionals’ awareness on acquired haemophilia: a cross-sectional study
Ali Taher, Layal Al Mahmasani, Abdallah Aadra, Patricia Yazbeck, Georges Abi Saad, Fadi Nasr, Rita Habib, Amal Chalfoun and Fadi Haddad 83
Intracellular ROS profile in hematopoietic progenitors of MDS patients: association with blast count and iron overload
Lap Shu Alan Chan, Lilly ChunHong Gu, Heather A. Leitch and Richard A. Wells 88
Impact of pre-transplant use of antibiotics on the graft-versus-host disease in adult patients with hematological malignancies
Myung-Won Lee, Sang-Hoon Yeon, Bu-Yeon Heo, Jaeyul Kwon, Hyewon Ryu, Hyo-Jin Lee, Hwan-Jung Yun, Deog-Yeon Jo and Ik-Chan Song 96
Hodgkin lymphoma involving extranodal sites in head and neck: report of twenty-nine cases and review of three-hundred and fifty-seven cases
Saad Akhtar, Yassir Khafaga, Wael Edesa, Mustafa Al-Mubarak, M. Shahzad Rauf and Irfan Maghfoor 103
Next-generation sequencing reveals gene mutations landscape and clonal evolution in patients with acute myeloid leukemia
Xiao Chen, Han Zhu, Chun Qiao, Sishu Zhao, Lu Liu, Yan Wang, Huimin Jin, Sixuan Qian and Yujie Wu 111
Analysis of the influencing factors related to liver and cardiac iron overload in MDS patients detected by MRI in the real world
Chao Xiao, Yao Zhang, Jun-gong Zhao, Lu-xi Song, You-shan Zhao, Yan Jia, Juan Guo, Shuang Han, Zhao-wei Li, Cha Guo, Xiao Li and Chun-kang Chang 123
Hematopoietic stem cell transplantation for inherited bone marrow failure syndromes: alternative donor and disease-specific conditioning regimen with unmanipulated grafts
Yue Lu, Min Xiong, Rui-Juan Sun, Yan-Li Zhao, Jian-Ping Zhang, Xing-Yu Cao, De-Yan Liu, Zhi-Jie Wei, Jia-Rui Zhou and Dao-Pei Lu 134
Association of cytotoxic T-lymphocyte antigen-4 (CTLA-4) single nucleotide polymorphism in donors with clinical outcome after allogeneic hematopoietic stem cell transplantation: a meta-analysis
Zhuo Wang, Yunwei Zhang, Yazhe Du, Fei Song and Sujun Gao 144
Myeloid/lymphoid neoplasm with CEP110-FGFR1 fusion: An analysis of 16 cases show common features and poor prognosis
Meiyu Chen, Kai Wang, Xiaohui Cai, Xiuwen Zhang, Hongying Chao, Suning Chen, Hongjie Shen, Qian Wang and Ri Zhang 153
Long non-coding RNA ANRIL and its target microRNAs (microRNA-34a, microRNA-125a and microRNA-186) relate to risk stratification and prognosis in multiple myeloma
Yafei Yin, Wenqun Yang, Lu Zhang, Kang Liu and Zimian Luo 160
HOTAIR suppresses PTEN via DNMT3b and confers drug resistance in acute myeloid leukemia
Wei Zhou, Shilin Xu, Xiaowei Chen and Caixia Wang 170
The effect of the detection of minimal residual disease for the prognosis and the choice of post-remission therapy of intermediate-risk acute myeloid leukemia without FLT3-ITD, NPM1 and biallelic CEBPA mutations
Wen-shuai Zheng, Ya-lei Hu, Li-xun Guan, Bo Peng and Shen-yu Wang 179
Allogeneic hematopoietic cell transplantation using fludarabine plus myeloablative busulfan and melphalan confers promising survival in high-risk hematopoietic neoplasms: a single-center retrospective analysis
Taro Edahiro, Takakazu Kawase, Hisao Nagoshi, Keita Fujino, Kayo Toishigawa, Takahiko Miyama, Tatsuji Mino, Tetsumi Yoshida, Takehiko Morioka, Yuji Hirata, Mitsunori Noma, Teruhisa Fujii, Masatoshi Nishizawa, Noriyasu Fukushima and Tatsuo Ichinohe 186
Management of sickle cell disease: current practices and challenges in a northeastern region of the Democratic Republic of the Congo
Paul Kambale-Kombi, Roland Marini Djang’eing’a, Jean-Pierre Alworong’a Opara, Jean-Marc Minon, François Boemer, Vincent Bours, Serge Tonen-Wolyec, Charles Kayembe Tshilumba and Salomon Batina-Agasa 199
Rapid Communication
Anticoagulation and bone marrow biopsy: is it safe to proceed?
Cameron Moore and Rouslan Kotchetkov 206
Articles
High expression of CD56 may be associated with favorable overall survival in intermediate-risk acute myeloid leukemia
Cunte Chen, Chi Leong Chio, Hui Zeng and Yangqiu Li 210
Ethnic differences in acute promyelocytic leukaemia between New Zealand Polynesian and European patients
Chris Varghese, Valery Yizhuo Liu, Tracey Immanuel, Nicole Chien, Taryn Green, George Chan, Edward Theakston and Maggie Kalev-Zylinska 215
Hematologic autoimmune disorders in the course of COVID-19: a systematic review of reported cases
Erfan Taherifard, Ehsan Taherifard, Hamed Movahed and Mohammad Reza Mousavi 225
A cost-effectiveness analysis of the prophylaxis versus on-demand regimens in severe hemophilia A patients under 12 years old in southern Iran
Zohreh Zahedi, Mehran Karimi, Khosro Keshavarz, Sezaneh Haghpanah and Ramin Ravangard 240
A 10-year cohort study of 175 primary gastrointestinal lymphoma cases in Thailand: clinical features and outcomes in the immunochemotherapy era
Weerapat Owattanapanich, Theera Ruchutrakool, Tawatchai Pongpruttipan and Monthira Maneerattanaporn 249
Case Report
Myelomonocytic differentiation of leukemic blasts accompanied by differentiation syndrome in a case of FLT3-ITD-positive AML treated with gilteritinib
Takeshi Kondo, Masahiro Onozawa, Shinichi Fujisawa, Shinpei Harada, Reiki Ogasawara, Koh Izumiyama, Makoto Saito, Masanobu Morioka, Akio Mori and Takanori Teshima 256
Articles
Persistence to hypomethylating agents and clinical and economic outcomes among patients with myelodysplastic syndromes
Wendy Y. Cheng, Ambika Satija, Hoi Ching Cheung, Kala Hill, Tim Wert, François Laliberté and Patrick Lefebvre 261
Safety and efficacy of different doses of anthracyclines combined with arsenic trioxide and all-trans retinoic acid in the treatment of de novo acute promyelocytic leukemia
Yaxue Wu, Peng Ke, Haixia Zhou, Depei Wu, Suning Chen, Huiying Qiu, Yue Han, Caixia Li, Xiao Ma, Aining Sun, Xiaowen Tang and Xiaohui Hu 271
Quality of life in patients with nonvalvular atrial fibrillation treated with oral anticoagulants
Miren Gabilondo, Jesús Loza, Angel Pereda, Ohiane Caballero, Nerea Zamora, Ania Gorostiza and Javier Mar 277
Identification of mast cells as a candidate significant target of immunotherapy for acute myeloid leukemia
Mingfeng Jia, Hao Zhang, Lina Wang, Long Zhao, Shengxuan Fan and Yaming Xi 284
Impact of pre-transplantation minimal residual disease (MRD) on the outcome of Allogeneic hematopoietic stem cell transplantation for acute leukemia
Xing Shen, Jing Pan, Chenchen Qi, Yuan Feng, Hanxin Wu, Sixuan Qian, Hua Lu, Lijuan Chen, Jianyong Li, Kourong Miao, Hairong Qiu and Han Zhu 295
Case Report
Differential diagnostic and treatment difficulties in a patient with acquired von Willebrand syndrome
Ferenc Magyari, Bertalan Kracskó, Judit Bedekovics, Zsuzsanna Bereczky, Árpád Illés and Ágota Schlammadinger 301
Articles
Congenital dysfibrinogenemia caused by γAla327Val mutation: structural abnormality of D region
Aiqiu Wei, Yangyang Wu, Liqun Xiang, Jie Yan, Peng Cheng, Donghong Deng and Faquan Lin 305
Hypomethylating agents in the treatment of chronic myelomonocytic leukemia: a meta-analysis and systematic review
Ruohao Xu, Minming Li, Ping Wu, Chengxin Deng, Suxia Geng, Xin Huang, Jianyu Weng and Xin Du 312
Rate of RhD-alloimmunization after the transfusion of RhD-positive red blood cell containing products among injured patients of childbearing age: single center experience and narrative literature review
Mark Yazer, Darrell Triulzi, Jason Sperry, Alain Corcos and Jansen Seheult 321
Infections in hematopoietic stem cell transplant patients admitted to Hematology intensive care unit: a single-center study
Tuğba Barlas, Kamil İnci, Gulbin Aygencel, Melda Türkoğlu, Özlem Güzel Tunçcan, Ferda Can, Lale Aydın Kaynar, Zübeyde Nur Özkurt, Zeynep Arzu Yeğin and Münci Yağcı 328
Allogeneic hematopoietic stem cell transplantation could improve the survival of acute myeloid leukemia patients with ASXL1 mutations
Lili Zhou, Jingnan An, Chang Hou, Zixuan Ding, Huiying Qiu, Xiaowen Tang, Aining Sun, Suning Chen, Yang Xu, Tianhui Liu and Depei Wu 340
Case Report
T cell ALL in a child with Ataxia telangiectasia; diagnosis and management challenges
Omaima Ahmed, Yara Felimban and Abeer Almehdar 348
Articles
Efficacy and safety of consolidation therapy with intermediate and high dose cytarabine in acute myeloid leukemia patients
Kittisak Tangchitpianvit, Ekarat Rattarittamrong, Chatree Chai-Adisaksopha, Pokpong Piriyakhuntorn, Thanawat Rattanathammethee, Sasinee Hantrakool, Adisak Tantiworawit and Lalita Norasetthada 355
2-Mercaptoethanol (2-ME)-based IATs or Polybrene method mitigates the interference of daratumumab on blood compatibility tests
Ye Zhou, Leiyu Chen, Tianshu Jiang, Liangfeng Fan, Hang Lei, Yuqing Wang, Hasiyati Heililahong, Jianqing Mi, Danxin Du, Tianhong Miao, Rong Xia, Xuefeng Wang, Dong Xiang, Xiaohong Cai and Xiaofeng Tang 365
Genetic features and efficacy of decitabine-based chemotherapy in elderly patients with acute myeloid leukemia
Bianhong Wang, Wei Guan, Na Lv, Ting Li, Fan Yu, Yuehua Huang, Yanying Wang, Lihong Li and Li Yu 371
High expression of TARP correlates with inferior FLT3 mutations in non-adolescents and young adults with acute myeloid leukaemia
Yuye Shi, Zhengmei He, Liye Bei, Hong Tao, Banghe Ding, Shandong Tao, Chunling Wang and Liang Yu 380
Feasibility of six cycles of lenalidomide-based triplet induction before stem cell collection for newly diagnosed transplant-eligible multiple myeloma
Satoshi Yoshihara, Kyoko Yoshihara, Yoshifumi Shimizu, Takehito Imado, Hiroyuki Takatsuka, Hiroyuki Kawamoto, Mahito Misawa, Hideki Ifuku, Yokiko Ohe, Masaya Okada and Yoshihiro Fujimori 388
Impact of obesity on survival of patients with myelodysplastic syndromes
Zaker Schwabkey, Najla Al Ali, David Sallman, Andrew Kuykendall, Chetasi Talati, Kendra Sweet, Jeffrey Lancet, Eric Padron and Rami Komrokji 393
Clinical utility of the updated European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and the Mycoses Study Group Education and Research Consortium computed tomography criteria of invasive pulmonary aspergillosis in hematological malignancies
Marta Hałaburda- Rola, Tomasz Dzieciątkowski, Michał Górka, Olgierd Rowiński and Laretta Grabowska- Derlatka 398
Screening and identification of key genes in imatinib-resistant chronic myelogenous leukemia cells: a bioinformatics study
Hong Zhang, Peiran Wang, Ting Song, Uwituze Laura Bonnette and Zhichao Zhang 408
Letter to the Editor
Chronic opioid use in patients with sickle cell disease
George Mo, Tim Jang, Connor Stewart, Leen Khoury, Natalie Ferguson, Ogechukwu Egini, John Muthu, Dibyendu Dutta, Moro Salifu and Seah H. Lim 415
Article
Integrated analysis on mRNA microarray and microRNA microarray to screen immune-related biomarkers and pathways in myelodysplastic syndrome
Chunyi Lyu, Kui Liu, Yuehua Jiang, Teng Wang, Yan Wang and Ruirong Xu 417
Letter to the Editor
Transfusion-dependent beta thalassemia in Afghanistan: current evidence amid COVID-19 and future recommendations
Shohra Qaderi, Sayed Hamid Mousavi, Attaullah Ahmadi, Shamim Arif, Shekiba Madadi, Sohrab Ayoubi and Don Eliseo Lucero-Prisno III 432
Article
Mixed chimerism after allogeneic hematopoietic stem cell transplantation for severe aplastic anemia
Yuling Zhang, Yumiao Li, Liangliang Wu, Ming Zhou, Caixia Wang, Wenjian Mo, Xiaowei Chen, Shilin Xu, Ruiqing Zhou, Shunqing Wang and Yuping Zhang 435
Rapid Communication
Low- and intermediate-risk myelodysplastic syndrome with pure red cell aplasia
Huaquan Wang, Haiyue Niu, Tian Zhang, Limin Xing, Zonghong Shao and Rong Fu 444
Articles
Polymorphisms in the GCK gene increase the risk of clopidogrel resistance in stable coronary artery disease (SCAD) patients
Hongyu Xu, Qinglin Yu, Honglin Zhou, Jin Yang, Nan Zheng, Zhifeng Xu and Jia Su 447
Identification of hub genes with prognostic values in multiple myeloma by bioinformatics analysis
Jie Yang, Fei Wang, Shanliang Zhong and Baoan Chen 453
Risk of hepatitis B virus reactivation following ruxolitinib treatment in patients with myeloproliferative neoplasms
Ming-hui Duan, Xin-Xin Cao, Long Chang and Dao-bin Zhou 460
Survival after acute episodes of immune-mediated thrombotic thrombocytopenic purpura (iTTP) – cognitive functioning and health-related quality of life impact: a descriptive cross-sectional survey of adults living with iTTP in the United Kingdom
Steve Holmes, Lauren Podger, Catherine Bottomley, Ewelina Rzepa, Karen M. A. Bailey and Fleur Chandler 465
The serum ferritin levels and liver iron concentrations in patients with alpha-thalassemia: is there a good correlation?
Nattiya Teawtrakul, Chittima Sirijerachai, Kanchana Chansung and Arunee Jetsrisuparb 473
Expression profile analysis reveals hub genes that are associated with immune system dysregulation in primary myelofibrosis
Haotian Ma, Jincen Liu, Zilong Li, Huaye Xiong, Yulei Zhang, Yanping Song and Jianghua Lai 478
Advances in the creation of animal models of paroxysmal nocturnal hemoglobinuria
Yingying Chen and Fu Rong 491
Effectiveness and safety of romiplostim among patients with newly diagnosed, persistent and chronic ITP in routine clinical practice in central and Eastern Europe: an analysis of the PLATON study
Barbara Skopec, Zuzana Sninska, Nikolai Tzvetkov, Vladlen Ivanushkin, Katja Björklöf, Jane Hippenmeyer and Georgi Mihaylov 497
Effects of long-term high-altitude exposure on fibrinolytic system
Peng Jiang, Zongkui Wang, Xiaochuan Yu, Yuyan Qin, Yuanzhen Shen, Chunhui Yang, Fengjuan Liu, Shengliang Ye, Xi Du, Li Ma, Haijun Cao, Pan Sun, Na Su, Fangzhao Lin, Rong Zhang and Changqing Li 503
Prognostic value of circulating clonal plasma cells in newly diagnosed multiple myeloma
Wenmin Han, Yuanyuan Jin, Min Xu, Si-Shu Zhao, Qinglin Shi, Xiaoyan Qu, Run Zhang, Jianyong Li, Yujie Wu and Lijuan Chen 510
Synergistic inhibitory effect of Smo inhibitor jervine and its combination with decitabine can target Hedgehog signaling pathway to inhibit myelodysplastic syndrome cell line
Fang Zhao, Jie Wang, Liu Yao, Yu-ting Qin, Niluopaer Tuerxun, Huan Wang, Ming Jiang and Jian-ping Hao 518
Hematological and biochemical parameters as diagnostic and prognostic markers in SARS-COV-2 infected patients of Pakistan: a retrospective comparative analysis
Atiqa Khalid, Muhammad Ali Jaffar, Tabinda Khan, Raees Abbas Lail, Sana Ali, Gulali Aktas, Abdul Waris, Amnah Javaid, Nouman Ijaz and Nasir Muhammad 529
The effect of Gö6976 on chronic myeloid leukemia in vitro and in vivo
Zhen-Rui Cao, Xiao-Peng Chen, Min Feng, Yun-Long Hou, Yan Li, Xiao-Lei Hu, Zheng-Lan Huang and Jing Hu 543
Case Report
Long-time remission of laryngeal Rosai–Dorfman disease with thalidomide: a report of three cases
Chong Wei and Dao-bin Zhou 552
Articles
Low serum albumin level deteriorates prognosis in azacitidine-treated myelodysplastic syndromes patients – results of the PALG study ‘PolAZA’
Krzysztof Mądry, Karol Lis, Andrzej Tukiendorf, Paweł Szwedyk, Katarzyna Kapelko-Słowik, Edyta Subocz, Aleksandra Gołos, Wioletta Makowska, Anna Masternak, Anna Kopińska, Magdalena Czemerska, Sara Zawadzka-Leska, Patrycja Rusicka, Joanna Drozd-Sokołowska, Elżbieta Wiater, Jadwiga Hołojda, Bartłomiej Pogłódek, Piotr Centkowski, Anna Waszczuk-Gajda, Rafał Machowicz, Janusz Hałka, Tomasz Czerw, Grzegorz Basak and Jadwiga Dwilewicz-Trojaczek 556
Stanniocalcin 1 is overexpressed in multipotent mesenchymal stromal cells from acute myeloid leukemia patients
Roland Christian Schelker, Andrea Kratzer, Gunnar Müller, Christoph Brochhausen, Christina Hart, Thomas Stempfl, Daniel Heudobler, Christoph Moehle, Wolfgang Herr, Sabine Iberl and Jochen Grassinger 565
Efficacy and safety of cladribine addition to induction treatment of newly diagnosed acute myeloid leukemia: a systematic review and meta-analysis
Qianying Pan and Juan Li 577
Letter to the Editor
Caution the masker of Good’s sydrome on the secondary pure red cell aplasia
Weiwei Chen, Lei Jiang and Jinlin Liu 588
Case Reports
Refractory acquired thrombotic thrombocytopenic purpura in a patient with sickle cell trait successfully treated with caplacizumab
Vibhuti Aggarwal, Zachary Singer, Donna Ledingham and Ibraheem Othman 590
Essential thrombocythaemia with aggressive megakaryocytosis after myelofibrotic transformation
Ko Sasaki, Yasuhito Nannya, Yuko Nakamura, Motoshi Ichikawa, Seishi Ogawa and Kinuko Mitani 594
Articles
The rebirth of the cool: a narrative review of the clinical outcomes of cold stored low titer group O whole blood recipients compared to conventional component recipients in trauma
Devin Dishong, Andrew P. Cap, John B. Holcomb, Darrell J. Triulzi and Mark H. Yazer 601
Therapist-oriented home rehabilitation for adults with sickle cell anemia: effects on muscle strength, functional capacity, and quality of life
Carlos Henrique Stohler de Almeida, Luis Felipe da Fonseca Reis, Leila Paula Alves da Silva Nascimento, Andrea Ribeiro Soares, Maria Christina Paixão Maioli and Agnaldo José Lopes 612
Role of folinic acid in methotrexate-based prophylaxis of graft-versus-host disease following hematopoietic stem cell transplantation
Naif I. AlJohani 620
New insight into the mechanism of granulocyte colony-stimulating factor (G-CSF) that induces the mobilization of neutrophils
Abdulrahman Theyab, Mohammad Algahtani, Khalaf F. Alsharif, Yousef M. Hawsawi, Abdulaziz Alghamdi, Adel Alghamdi and Jude Akinwale 628
Patient vital signs in relation to ICU admission in treatment of acute leukemia: a retrospective chart review
Katharine McLaughlin, Amanda Stojcevski, Abdulkadir Hussein, Devinder Moudgil, Indryas Woldie and Caroline Hamm 637
Letter to the Editor
Donor cell leukemia/myelodysplastic syndrome after allogeneic stem cell transplantation: a rare phenomenon with more challenges for hematologists
Suping Zhang, Li Li, Weijie Cao, Yingmei Li, Zhongxing Jiang, Jifeng Yu and Dingming Wan 648
Articles
3-weekly daratumumab-lenalidomide/pomalidomide-dexamethasone is highly effective in relapsed and refractory multiple myeloma
Chor Sang Chim, Shaji Kumar, Vincent Kai Chung Wong, Cheong Ngai and Yok Lam Kwong 652
Association of coagulation disturbances with severity of COVID-19: a longitudinal study
Huimin Lu, Ming Chen, Shaoqiu Tang and Wenkui Yu 656
Effects of ruxolitinib on infection in patients with myeloproliferative neoplasm: a meta-analysis
Qingsong Luo, Zhiji Xiao and Liming Peng 663
Bridging antifungal prophylaxis with micafungin in hematopoietic stem cell transplantation: a retrospective analysis
Haiyan Zhang 670
Original Research
Latent Epstein–Barr virus infection status and prognosis in patients with newly diagnosed Hodgkin lymphoma in Southeast China: a single-center retrospective study
Chang Wang, Si-Ping Zou, Dao-Guang Chen, Jie-Song Wang, Yan-Bin Zheng, Xiu-Rong Chen and Yu Yang 675
Article
Variations and characteristics of the various clinical phenotypes in a cohort of Nigerian sickle cell patients
Augustine Duru, Anazoeze Jude Madu, Helen Okoye, Charles Nonyelu, Onochie Obodo, Kelechi Okereke and Kenechi Madu 684
Case Report
A case of a patient characterized by t(8;22)(p11;q11) and BCR/FGFR1 fusion gene, who was successfully treated with haploidentical hematopoietic stem cell transplantation
Xin Chen, Lifang Huang, Caifeng Zheng and Zhiqiong Wang 691
Articles
Treatment patterns in adults with immune thrombocytopenia before, during and after use of thrombopoietin receptor agonists: a longitudinal prescription database study from Germany
Oliver Meyer, Hartmut Richter, Andrea Lebioda and Markus Schill 697
Evaluation of routine CT scans in the follow-up of diffuse large B-cell lymphomas
Martí Mascaró-Pol, Ramón Díez-Feijoo, Juan Jose Rodriguez-Sevilla, Concepción Fernández-Rodriguez, Francesc García-Pallarols, Solange Flores, Ivonne Vazquez, Saray Rodriguez-Lopez, David Roman, Eva Gimeno, Luis Colomo, Jose Maiques, Blanca Sánchez-González and Antonio Salar 709
CircRNA circ_0001821 predicts an unfavorable prognosis and promotes the proliferation of multiple myeloma
Lin Liu, Feng Zhang and Jiajia Li 716
The role of macrophages and osteoclasts in the progression of leukemia
Kun Li, Runming Jin and Xiaoyan Wu 724
Decreasing lncRNA PVT1 causes Treg/Th17 imbalance via NOTCH signaling in immune thrombocytopenia
Ling Yu, Liqin Zhang, Zhiyong Jiang and Beiwei Yu 734
A comparative study of porcine antihuman lymphocyte globulin versus antithymocyte globulin-fresenius in an allogeneic hematopoietic cell transplantation conditioning regimen for severe aplastic anemia
Yanming Zhang, Limin Liu, Yejun Si, Miao Miao, Huiying Qiu, Xiaowen Tang, Yue Han, Chengcheng Fu, Zhengming Jin, Suning Chen, Aining Sun and Depei Wu 741
Outcomes of newly diagnosed acute myeloid leukemia with myelodysplasia related changes and elderly acute myeloid leukemia following decitabine therapy in combination with priming regimen
Binbin Lai, Qitian Mu, YanLi Zhang, Ying Chen, Xiao Yan and Guifang Ouyang 751
Role of matrix metalloproteinase MMP-2, MMP-9 and tissue inhibitor of metalloproteinase (TIMP-1) in the clinical progression of pediatric acute lymphoblastic leukemia
Maha Saleh, Mohamed Khalil, Mona S. Abdellateif, Emad Ebeid, Youssef Madney and Eman Z. Kandeel 758
Comparative study between two bleeding grading systems of immune thrombocytopenia purpura
Qiuni Chen, Yijing Zhang, Yunjie Li, Lijuan Zhang, Wenting Shi, Hong Tao, Kankan Chen, Zhengmei He, Chunling Wang and Liang Yu 769
Effect of hypoxia on proliferation and glucocorticoid resistance of T-cell acute lymphoblastic leukaemia
Yuanyuan Li, Yi Wei and Ling Gu 775
Management of ibrutinib treatment in patients with B-cell malignancies: clinical practice in Portugal and multidisciplinary recommendations
José Pedro Carda, Lurdes Santos, José Mário Mariz, Pedro Monteiro, Humberto Miguel Gonçalves, João Raposo and Maria Gomes da Silva 785
Patient preferences and experiences regarding thrombopoietin-receptor agonists for immune thrombocytopenia in the United Kingdom and Ireland (TRAPeze UK & IE study)
Vickie McDonald, Adrian Newland, Mervyn Morgan, Koo Wilson, Jameel Nazir, Peter Maguire, Emma Geldman and Tammy Wynne 799
Cytokine release syndrome after haploidentical hematopoietic stem cell transplantation with antithymocyte globulin: risk factors analysis and poor impact on outcomes for non-remisssion patients
Ziwei Xu, Xi Zhou, Xiaoyan Zhao, Xuan Lu, Liang Tang, Wei Shi, Han Yan, Yong You and Huafang Wang 809
Lenalidomide improves the antitumor activity of CAR-T cells directed toward the intracellular Wilms Tumor 1 antigen
Li Zhang, Guangyi Jin, Ziren Chen, Changhua Yu, Yonghui Li, Yisheng Li, Jinghong Chen and Li Yu 818
Efficacy of cytochemical tests in gene analysis of hereditary spherocytosis: a case study of six patients with different disease subtypes
Atsushi Shibuya, Hiroaki Kawashima and Masato Tanaka 827
Case Report
Passenger lymphocyte syndrome after ABO-incompatible allogeneic hematopoietic stem cell transplantation; dynamics of ABO allo-antibody and blood type conversion
Haruka Teshigawara-Tanabe, Maki Hagihara, Ayako Matsumura, Hiroyuki Takahashi, Yuki Nakajima, Takuya Miyazaki, Aki Kamijo, Etsuko Yamazaki, Katsumichi Fujimaki, Kenji Matsumoto and Hideaki Nakajima 835
Articles
miR-149-3p suppressed epithelial–mesenchymal transition and tumor development in acute myeloid leukemia
Yaoyao Tian, Yongfang Jiang, Xiushuai Dong, Yuying Chang, Jia Chi and Xi Chen 840
Clinical values of gene alterations as marker of minimal residual disease in non-M3 acute myeloid leukemia
Tingyu Yu, Jianxiang Chi and Li Wang 848
Characterization and treatment of immune thrombocytopenia in Europe: a qualitative observational study
Edgar A. Pogna, Simon Middleton, Jameel Nazir, Leah Ralph, Koo Wilson and Wojciech Jurczak 860
Case Report
Could COVID-19 induce remission of acute leukemia?
Eman Z. Kandeel, Lobna Refaat, Raafat Abdel-Fatah, Mohamed Samra, Ahmed Bayoumi, Mona S. Abdellateif, Hend Abdel-Hady, Mohamed Ali and Medhat Khafagy 870
Article
Impact of iron overload by transfusion on survival and leukemia transformation of myelodysplastic syndromes in a single center of China
Yihao Wang, Lei Huang, Yanni Hua, Hui Liu, Huijuan Jiang, Huaquan Wang, Wei Zhang, Rong Fu and Zonghong Shao 874
Rapid Communication
Mean corpuscular volume, hematocrit and polycythemia
Leonid L. Yavorkovsky 881
Article
Circ_0000745 regulates NOTCH1-mediated cell proliferation and apoptosis in pediatric T-cell acute lymphoblastic leukemia through adsorbing miR-193b-3p
Huanhuan Feng, Fei Li and Ping Tang 885
Case Report
Ferritin L-subunit gene mutation and hereditary hyperferritinaemia cataract syndrome (HHCS): a case report and literature review
Yunfan Yang, Ting Lin, Pu Kuang and Xinchuan Chen 896
Article
Comprehensive DNA repair gene expression analysis and its prognostic significance in acute myeloid leukemia
Sholhui Park, Yi-Jun Kim, Hee Jin Huh, Hae-Sun Chung, Miae Lee, Young Mi Park, Yeung Chul Mun, Chu-Myong Seong and Jungwon Huh 904
Case Report
Cyanosis, hemolysis, decreased HbA1c and abnormal co-oximetry in a patient with hemoglobin M Saskatoon [HBB:c.190C > T p.His64Tyr]
Eva-Leonne Göttgens, Kristian Baks, Cornelis L. Harteveld, Kristel Goossens and Adriaan J. van Gammeren 914
Articles
Prognostic significance of ferroptosis-related genes and their methylation in AML
Fang Zhou and Baoan Chen 919
MiR-204 suppresses the progression of acute myeloid leukemia through HGF/c-Met pathway
Dingrui Nie, Ping Ma, Yanli Chen, Huayan Zhao, Lin Liu, Dao Xin, Weijie Cao, Fang Wang, XiaoLi Meng, Linxiang Liu, Menghan Xie and Ling Sun 931
Diagnostic concordance of pathological methods and reports of hematopathologists compared to local nonspecialized pathologists in the diagnosis of lymphoma in Mexico
Manuel Solano Genesta, Luis Alberto Garcia Gonzalez, Francisco Javier Rubio Macias, Leonora Valdez Rojas, Cristina Alejandra Luna Gonzalez, Oscar de Jesus Perez Ramirez, Adrian Alejandro Ceballos Lopez, Alvaro Cabrera Garcia, Luis Arteaga Ortiz, Ramon Martinez Hernandez, David Gomez-Almaguer, Maria del Carmen Lome Maldonado, P. Yuridia L. Alvarado Bernal, Alejandra Zarate Osorno, Jose Regalado Ramos, Paula Barreyro and Miguel Angel Herrera Rojas 940
Efficacy of ondansetron against emesis induced by a multiple-day cisplatin-based chemotherapy regimen for malignant lymphoma
Takahiro Kamiya, Masatoshi Sakurai, Taku Kikuchi, Mikio Okayama, Kota Mizuno, Tomohiko Tanigawa, Yuya Koda, Jun Kato and Takehiko Mori 945
Efficacy and cost of G-CSF derivatives for prophylaxis of febrile neutropenia in lymphoma and multiple myeloma patients underwent autologous hematopoietic stem cell transplantation
Xiaoning Wang, Juan Ren, Xiao Liang and Pengcheng He 950
Development and validation of a nomogram for steroid-resistance prediction in immune thrombocytopenia patients
Jieni Yu, Zhiqiang Xu, Yuanyuan Zhuo, Huahua Wei, Yinhai Ye, Qinhong Xu, Youli Li, Lihong Yu, Weiying Feng, Pan Hong and Kejie Zhang 956
Letter to the Editor
Identification of novel combined biomarkers in the diagnosis of multiple myeloma
Yanxia Jin, Yuxing Liang, Yanting Su, Lingyun Hui, Hailing Liu, Lu Ding and Fuling Zhou 964
Articles
Neutrophil CD64: a potential biomarker for the diagnosis of infection in patients with haematological malignancies
Jiabao Liang, Jiayu Xu, Lu You, Guolei Yang, Guomin Niu, Huanyu Pan, Sijian Yu, Xiuqu Mai, Jialiang Xu and Fuhua Zhang 970
Identification of key miRNA signature and pathways involved in multiple myeloma by integrated bioinformatics analysis
Xiushuai Dong, Gang Lu, Xianwei Su, Jie Liu, Xi Chen, Yaoyao Tian, Yuying Chang, Lianjie Wang, Wei Wang and Jin Zhou 976
Research progress on treatment of extramedullary multiple myeloma
Yue Chen, Shandong Tao, Xinqi Zheng, Yuye Shi, Lijuan Zhang, Kankan Chen, Zhengmei He, Chunling Wang and Liang Yu 985
Optimal time-points for detecting expression levels of BAALC, EVI1, and WT1 genes in patients with acute myeloid leukemia: a meta-analysis
Ka-Yuk Yuen, Xiao-Ying Lin, Yong-Zhuo Zhou, Hua Luo, Yong Liu and Lu-Hong Xu 995
Haematological profile of COVID-19 patients from a centre in Singapore
Valencia Shihuan Long, Jinghao Nicholas Ngiam, Nicholas Chew, Sai Meng Tham, Zhen Yu Lim, Tony Li, Shuyun Cen, Jayagowtham K. Annadurai, Sandi Myo Thant, Paul Anantharajah Tambyah, Amelia Santosa, Winnie Z.Y. Teo, Eng Soo Yap, Gail Brenda Cross and Ching-Hui Sia 1007
Sublingual methylcobalamin treatment is as effective as intramuscular and peroral cyanocobalamin in children age 0–3 years
Betül Orhan Kiliç, Serhat Kiliç, Elif Şahin Eroğlu, Eylem Gül and Fatma Burcu Belen Apak 1013
The role of circular RNA plasmacytoma variant translocation 1 as a biomarker for prognostication of acute myeloid leukemia
Tao Chen and Fengyun Chen 1018
Treatment outcome of 301 aplastic anemia patients in China: a 10-year follow-up and real-world data from single institute experience
Xiao-tian Zhang, Xue Wang, Jiang Cao, Wei Chen, Kun-ming Qi, Na Qi, Fei Liang, Xue-yan Dong, Guo-feng Tang, De-peng Li, Wei Sang, Zhen-yu Li, Hai Cheng and Kai-lin Xu 1025
Efficacy and safety of ixazomib maintenance therapy for patients with multiple myeloma: a meta-analysis
Huixian Chen, Yongjing Wang, Chunchun Shao, Chenxi Sun and Chengyun Zheng 1031
Low dose of homoharringtonine and cytarabine-based priming induction regimens for patients with de novo acute myeloid leukemia and high-risk myelodysplastic syndrome aged over 70 years
Fang Wang, Wenyan Xu, Li Liu, Xiuhong Ren, Pingping Liu, Li Zheng, Hao Zhang, Songsong Zhang, Yaru Xu and Zhenxing Guo 1040
Association between TNF-α gene polymorphisms and susceptibility of myelodysplastic syndromes: a meta-analysis
Tao Zhou, Sun-Jun Yin, Ping Wang, Yu-Xin Fan, Zhi-Ran Li, Qin Yang, Yan-Hua Huang, Rui Meng and Gong-Hao He 1046
Acute arrest of hemopoiesis presenting as severe aplastic anemia: a retrospective analysis
Danfeng Zhang, Jifeng Yu, Lingling Liu, Fang Wang, Shujuan Wang, Xinsheng Xie, Yingmei Li, and Zhongxing Jiang 1057