Reaction of pyridothiouracil with hydrazonoyl halides and the antimicrobial activity of the products, pyrido[2,3-d][1,2,4]triazolo-[4,3-a]pyrimidin-5(1H)-one derivatives

Abstract

New functionalized pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-one derivatives were synthesized via reaction of the hydrazonoyl halides with 7-(4-nitrophenyl)-5-phenyl-2,3-dihydro-2-thioxopyrido[2,3-d]pyrimidin-4(1H)-one or its 2-methylthio derivative. The biological activity of the products has been evaluated. The mechanism and the regioselectivity of the studied reactions have been discussed.

Keywords:

• Hydrazonoyl halides
• 2-Thiouracil
• Thiohydrazonates