Synthesis and antibacterial activities of some 2-amino-4-(1,1′-biphenyl-4-yl)-6-aryl-6H-1,3-thiazines

Abstract

A series of new 2-amino-4-(1,1′-biphenyl-4-yl)-6-aryl-6H-1,3-thiazines has been synthesized, characterized by IR, ¹H NMR, ¹³C NMR, mass and elemental analyses and evaluated for in vitro antibacterial activity against some Gram-positive and Gram-negative bacteria. The antibacterial data revealed that the compounds had better activity against tested organisms than the reference norfloxacin.

Keywords:

• 1,3-Thiazines
• Antibacterial activity
• 2-Amino-1,3-thiazines