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Research Article

Two-component, one-pot synthesis of pyrimido[1,2-b] [1,2,4,5]tetrazines

Pages 605-615 | Received 11 Jun 2006, Published online: 01 Feb 2007
 

Abstract

Derivatives containing the cyclohepta4′,5′thieno[2′,3′:4,5]pyrimido[1,2-b][1,2,4,5]-tetrazin-6-one system were prepared from the reaction of 3-amino-2-thioxo-1,2,3,5,6,7,8,9-octahydro-4H-cyclohepta[4,5]thieno[2,3-d]pyrimidin-4-one (5) or its 2-methylthio derivative 6 with hydrazonoyl chlorides 9. The mechanism of the studied reactions has been discussed and the biological activity of the isolated products has been evaluated.

Acknowledgements

The author wishes to offer grateful thanks to H. Mansour, at Brock University, Department of Biology, St. Catharines, Ontario, Canada for biological screening. The author is also thankful to NRC (Egypt) and Brock University (Canada) for facilities provided during the progress of this research. Dedicated to Professor A. S. Shawali on his birthday.

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