Abstract
2-Mercaptoquinoline substituted 1,2,3,4-tetrahydropyrimidinones have been efficiently synthesized in high yields in a short reaction time using TiCl3 as catalyst, in THF solvent. The mechanism is proposed based on the presence of Lewis acid catalyst in Biginelli condensation.
Acknowledgements
One of the author S. Ramesha is thankful to the UGC, New Delhi, for awarding Rajiv Gandhi Research Fellowship.