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Journal of Sulfur Chemistry Volume 29, 2008 - Issue 6
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Research Articles

Phloroglucinol sulfonic acid esters as antimalarial/anticancer agents

Erin E. Chapman Department of Chemistry, Mount Allison University, Sackville, New Brunswick, Canada
,
Richard F. Langler Department of Chemistry, Mount Allison University, Sackville, New Brunswick, CanadaCorrespondence[email protected]
&
Ian Crandall McLaughlin-Rotman Centre, MaRS Centre, University Health Network and the University of Toronto, Toronto, Ontario, CanadaCorrespondence[email protected]
Pages 607-618 | Received 06 Mar 2008, Published online: 22 Nov 2008
 
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Abstract

The synthesis and biological testing of some phloroglucinol-derived trisulfonates and sulfonate methyl ethers has established that the tritosylate 12 is a good in vitro antimalarial agent and that the dinosylate methyl ether 19 is a superior agent for inhibiting human skin cancer cell lines.

Acknowledgements

Technical assistance was provided by A. Bardon. High-field NMR spectra were obtained by D. Durant and mass spectra were obtained by R. Smith.

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