An efficient synthesis of 1,5-benzothiazepines in the presence of sub-stoichiometric amount of cyanuric chloride

Abstract

An efficient synthesis of 1,3-diaryl-2,3-dihydro-1,5-benzothiazepines has been developed by the reaction of various 1,3-diaryl-2-propenones with 2-aminothiophenol under thermal solvent-free conditions in the presence of a sub-stoichiometric amount of cyanuric chloride.

Keywords:

• 1,5-benzothiazepines
• 2-aminothiophenol
• cyanuric chloride
• synthesis

Acknowledgements

We are pleased to acknowledge the financial support from Xinxiang Medical University.