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Original Articles

Three-component reaction between 6-amino-N,- dimethyluracil and ammonium thiocyanate in the presence of aroyl chlorides under solvent-free conditions

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Pages 557-561 | Received 21 Jul 2011, Accepted 30 Aug 2011, Published online: 03 Oct 2011
 

Abstract

A novel method for the pyrimidine ring formation is established using the reaction of ammonium thiocyanate and aroyl chlorides with 6-amino-N,-dimethyluracil under solvent-free conditions to afford the functionalized pyrimido[4,5-d]pyrimidines in excellent yields.

Acknowledgement

The authors gratefully acknowledge the financial support from the Research Council of Islamic Azad University of Yazd and the Islamic Azad University of Zahedan of Iran.

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