Abstract
A novel method for the pyrimidine ring formation is established using the reaction of ammonium thiocyanate and aroyl chlorides with 6-amino-N,-dimethyluracil under solvent-free conditions to afford the functionalized pyrimido[4,5-d]pyrimidines in excellent yields.
Acknowledgement
The authors gratefully acknowledge the financial support from the Research Council of Islamic Azad University of Yazd and the Islamic Azad University of Zahedan of Iran.