A simple and efficient procedure for synthesis of optically active 1,2-bis(s-triazolo (Bis (S-triazolo[3,4-b][1,3,4]thiadiazole-3-yl) alkane derivatives containing L-amino acid moieties

Abstract

A series of 1,2-bis(s-triazolo (Bis (S-triazolo[3,4-b][1,3,4]thiadiazolo-3-yl)alkanes 3a–3k were prepared by condensation reaction of 1,2-bis(4-amino-5-mercapto-S-triazol-3-yl)alkanes 1a–1c with N-phetaloyl-l-amino acids 2a–2d in the presence of the phosphoroxy chloride (POCl₃) as an anhydrous reagent.

Keywords:

• N-phetaloyl-l-amino acid
• triazole
• triazolothiadiazole
• phosphoroxy chloride
• optically active

Acknowledgement

We gratefully acknowledge the financial support from the Research Council of Arak University.