A simple and efficient approach for the sulfonylation of indoles catalyzed by CuI

Abstract

In this paper, a simple and efficient protocol for the chemoselective sulfonation of indoles using aryl sulfonyl chlorides in the presence of CuI is reported. The reaction proceeds under mild conditions and is applicable to indoles bearing a selection of functional groups without NH protection.

Keywords:

• sulfonylation
• copper iodide
• sulfonyl chlorides
• indoles

Acknowledgements

A.H. and A.M. thank DST (Grant No. SR/S5/GC-05/2010) for the financial support. M.R. and M.G. thank CSIR and UGC, respectively, for their fellowship. The authors thank DST-FIST and UGC-SAP.