An efficient synthesis of [1,3,4]thiadiazolo[2,3-c][1,2,4] triazin-4-ones

Abstract

A three-component reaction between 4-amino-6-methyl-3-thioxo-3,4-dihydro-2H-[1,2,4]triazin-5-one, ammonium thiocyanate and aroyl chlorides in the presence of N-methylimidazole to afford the [1,3,4]thiadiazolo[2,3-c][1,2,4]triazin-4-ones in excellent yields is described.

Keywords:

• N-methylimidazole
• aroyl chlorides
• ammonium thiocyanate
• AMTTO
• three-component reaction

Acknowledgement

We gratefully acknowledge financial support from the Research Council of Islamic Azad University of Yazd of Iran.