Abstract
The electrosynthesis of new 2,4-dialkylcarbonotrithioates, in satisfactory yields, starting from arylthiols and carbon disulfide using an electrogenerated base (EGB) that is reported to promote the reaction is reported. The EGB was prepared by pro-base-free electrolysis of acetonitrile under galvanostatic conditions using a sacrificial magnesium anode. The as-prepared compounds were fully characterized by 1H, 13C, 19F NMR spectroscopy and mass spectrometry. The antimicrobial and cytotoxic activities of some representative compounds were investigated against human pathogenic bacteria, colon and lung cancer cell lines. Promising results were found against gram-positive and gram-negative bacteria and DLD-1 and A-549 cancer cell lines.
GRAPHICAL ABSTRACT
Acknowledgements
Dr M.A.K. Sanhoury, MRSC from the Department of Chemistry, Faculty of Sciences of Tunis for technical assistance.
Disclosure statement
No potential conflict of interest was reported by the authors.
Funding
The authors wish to thank the Tunisian Ministry of High Education and Scientific Research and Technology for financial support (Lab CH-02) of this research.
ORCID
Nejib Hussein Mekni http://orcid.org/0000-0003-2924-3551