Facile and convenient synthesis of 2,4-disubstituted and 2,3,4-trisubstituted 1,3-thiazoles

ABSTRACT

An efficient route for the synthesis of (E)-2-(2-(2-nitrobenzylidene)-hydrazinyl)-4-phenylthiazol-3-ium bromide, (E)-2-(2(substituted benzylidene)hydrazinyl)-4-phenylthiazoles and (E)-4-(4-bromophenyl)-2-(cycloalkylidenehydrazono)-3-phenyl-2,3-dihydrothiazoles by reaction of 1-aryl-2-bromoethanones with 2-(1-substituted methylidene)hydrazinecarbothioamides and cycloalkylidene-N-phenyl-hydrazinecarbothioamides. The structure of the products has been confirmed by using IR, NMR, mass spectrometry and single-crystal X-ray analyses.

GRAPHICAL ABSTRACT

KEYWORDS:

• Aryl-2-bromoethanones
• hydrazinecarbothioamides
• cyclo-alkylidenehydrazine carbothioamides
• Di- and trisubstituted-1,3-thiazoles
• thiazolium bromide derivative

Disclosure statement

No potential conflict of interest was reported by the authors.

Funding

This work was supported by NSF-MRI Grant #1228232 and Tulane University .