Ultrasound and water-mediated synthesis of bis-thiazoles catalyzed by Fe(SD)₃ as Lewis acid-surfactant-combined catalyst

ABSTRACT

Preparation of bis-aminothiazoles under different conditions including synthesis in EtOH under ultrasound irradiation and also in water in the presence of Fe(SD)₃ as Lewis acid-surfactant-combined catalyst (LASC) under ultrasound irradiation has been studied. The results were compared with the traditional reflux method. Also, the results confirmed the efficiency of the synthesis in water and under ultrasound irradiation technique. Moreover, the antibacterial activity of products was investigated using the well-diffusion method against bacterial strains including Micrococcus luteus, Escherichia coli, Pseudomonas aeruginosa and Bacillus subtilis. All of the products showed good antibacterial activity against M. luteus and E. coli. Most of the products showed antibacterial activity higher than erythromycin against M. luteus, E. coli, and B. subtilis.

GRAPHICAL ABSTRACT

KEYWORDS:

• Bis-aminothiazole
• antimicrobial activity
• ultrasound
• Fe(SD)₃
• green synthesis

Acknowledgements

The authors are grateful to the Research Council of University of Guilan for financial support of this work. Also, the authors appreciate the support of M. Rasa from Department of Biology, Faculty of Sciences, University of Guilan for antibacterial assay.

Disclosure statement

No potential conflict of interest was reported by the authors.