Synthesis and antioxidant activity of some new thioglycoluril derivatives

ABSTRACT

A series of S-alkylated products was prepared by alkylation of thioglycoluril with various alkylation agents, i.e. ethyl bromide, ethylene dibromide and chloroacetic acid. The synthesis performed in DMF at 60°C using sodium hydroxide as a base to give the corresponding products with significant advantages such as high conversions, short reaction time, mild reaction conditions, and low cost, simple workup with moderate to excellent yields. The structures of the synthesized compounds have been deduced from their spectral (IR, ¹H-NMR and ¹³C-NMR) data. Significant antioxidant activity was observed for some members of the series.

GRAPHICAL ABSTRACT

KEYWORDS:

• Thioglycoluril
• alkylation
• alkyl halides
• thioamides
• antioxidant activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This study was supported by the Ministry of Education and Science of the Russian Federation [grant number 05-13108].