New one-pot synthesis of 2-ylidenehydrazono-thiazoles

Abstract

A new one pot reaction of substituted thiosemicarbazides with 2-bromoacetophenone and carbonyl compounds gave 2-hydrazonothiazoles in good yields. The structures of the isolated compounds were corroborated by NMR, IR, mass spectra and elemental analyses in addition to X-ray structure determination.

GRAPHICAL ABSTRACT

KEYWORDS:

• Substituted thiosemicarbazides
• 2-bromoacetophenone
• carbonyl compounds
• 2-ylidine-hydrazinothiazoles
• NMR
• X-ray

Acknowledgements

The NMR spectrometer at Florida Institute of Technology was purchased with assistance from the U.S. National Science Foundation (CHE 03-42251).

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The NMR spectrometer at Florida Institute of Technology was purchased with assistance from the U.S. National Science Foundation (CHE 03-42251).