ABSTRACT
An efficient copper-catalysed tandem reaction to synthesize thiazol-2(3H)-one structures from readily available raw materials is described. The protocol provides a cost-effective approach to a decent range of nitrogen and sulfur bearing heterocycles in acceptable yields. The transformation takes place with CuCl as catalyst, N-methylpiperidine as additive, and t-BuOK as base in anhydrous DMF as solvent.
GRAPHICAL ABSTRACT
![](/cms/asset/9c1e5b32-1d5b-4051-9d10-9df731b214ba/gsrp_a_1703987_uf0001_oc.jpg)