ABSTRACT
A mixed bases mediated protocol is developed to synthesize thioamides from N-aryl or N-alkylamide, aldehyde and elemental sulfur in water. This reaction requires no addition of external oxidant and avoids large excess of amides. Various functional groups and pharmaceutically interesting heteroaromatic rings could be introduced via this efficient procedure.
GRAPHICAL ABSTRACT
Disclosure statement
No potential conflict of interest was reported by the author(s).
ORCID
Bingxin Yuan http://orcid.org/0000-0003-4580-366X
Correction Statement
This article has been republished with minor changes. These changes do not impact the academic content of the article.