The synthesis of biologically active 1-sulfonyl-1, 2, 3-triazoles from sulfonyl azides and alkynes: a focus review

Abstract

In this review, we spotlight the methods for the direct synthesis of synthetically and biologically important 1-sulfonyl-1, 2, 3-triazoles via [3+2] cycloaddition between easily available terminal alkynes and sulfonyl azides. The review is divided into two major sections. The first section focuses exclusively on the synthesis of 1-(N-sulfonyl)-4-substituted 1,2,3-triazoles, while the second section will discuss preparation of 1-(N-sulfonyl)-5-substituted 1,2,3-triazole derivatives.

GRAPHICAL ABSTRACT

KEYWORDS:

• Azide–alkyne cycloaddition
• 1-(N-sulfonyl)-1,2,3-triazoles
• sulfonyl azides
• alkynes
• copper catalysts

Disclosure statement

No potential conflict of interest was reported by the author(s).