Synthesis, spectroscopic characterization, and in vitro antimicrobial study of novel organotellurium (IV) diphenyldithiocarbamate derivatives

ABSTRACT

Three novel organotellurium (IV) derivatives of diphenyldithiocarbamate, C₄H₈Te[(CS₂) N(C₆H₅)₂]₂ (1), (C₂H₅)₂Te[(CS₂) N(C₆H₅)₂]₂ (2), and C₄H₇(CH₃)Te[(CS₂) N(C₆H₅)₂]₂ (3) have been synthesized by the reaction of sodium salt of diphenyl dithiocarbamate with C₄H₈TeI₂, (C₂H₅)₂TeI₂, and C₄H₇(CH₃)TeI₂ respectively. The synthesized compounds 1–3 were characterized by elemental analysis, IR, ¹H NMR, and ¹³C{¹H} NMR spectroscopic studies. The antimicrobial efficacy of compounds 1–3 was examined against selected bacterial and fungal strains using broth microdilution and disc diffusion methods. Penicillin and amphotericin B were used as a positive control for bacterial and fungal strains respectively. The highest activity against bacterial strains was shown by compound 3 while against the fungal strain compound 1 showed the highest activity with a MIC value of 6.25 µg/ml. However, all compounds showed high to moderate antimicrobial activity.

GRAPHICAL ABSTRACT

KEYWORDS:

• Organotellurium
• dithiocarbamate
• characterization
• spectroscopic study
• antimicrobial

Acknowledgements

This work was supported by the Department of Chemistry, Amity School of Applied Sciences, Amity University Lucknow-Campus, U.P., India, Department of Chemistry, Navyug Kanya Mahavidyalaya, Lucknow, Affiliated to University of Lucknow, U.P., India, and Department of Microbiology, Central University of Punjab, Bathinda, India.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

The authors confirm that the data supporting the findings of this study are available within the article.