Development and evaluation of a drug-in-adhesive transdermal delivery system for delivery of olanzapine

ABSTRACT

Objectives

Olanzapine (OZP) is a safe and effective atypical antipsychotic drug used in treating schizophrenia and bipolar disorders. The dosage forms currently on the market for OZP are administered via oral or intramuscular routes. However, there are many problems associated with oral and intramuscular routes of drug administration. Thus, our aim was to develop a drug-in-adhesive transdermal delivery system (TDS) that can deliver OZP for 3 days.

Methods

We determined passive permeation, effect of oleic acid as chemical enhancer, and delivery of OZP across different skin types. Based on preliminary studies and saturation solubility of OZP in different pressure-sensitive adhesives (PSAs), we formulated and characterized solution-based TDS in acrylate PSA and suspension-based TDS in silicone and PIB PSA, with oleic acid as chemical enhancer.

Results

Acrylate solution-based TDS, silicone, and PIB suspension-based TDS delivered 58.97 ± 6.59 µg/sq.cm, 129.34 ± 16.59 µg/sq.cm, and 245.00 ± 2.51 µg/sq.cm, respectively, using in vitro permeation testing. PIB PSA suspension-based TDS met the 3 days desired target delivery. Skin irritation testing using In vitro EpiDerm^TM skin irritation test (EPI-200-SIT) kit found PIB TDS to be nonirritant.

Conclusion

The PIB PSA suspension-based TDS could serve as a potentially effective transdermal delivery system for olanzapine.

KEYWORDS:

• Transdermal drug delivery
• pressure-sensitive adhesives
• chemical enhancers
• transdermal delivery systems
• skin irritation testing

Declaration of interest

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Reviewer disclosures

Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.

Author contributions

D Vora: Conceptualization, methodology, formal analysis, investigation, writing-original draft; AK Banga: Conceptualization, supervision, and writing-reviewing and editing. All authors have read and agree to the published version of the manuscript.

Additional information

Funding

This paper was not funded.