ABSTRACT
Introduction
Insulin plays a critical role in metabolism modulation including carbohydrate, lipid, and protein metabolism. There is room to improve insulin delivery but optimizing the best carrier remains challenging. Traditional and conventional approaches for insulin delivery do not emulate the normal fate of insulin release in the body. Despite extensive research attempts to overcome this and other challenges, the goal of achieving optimal insulin delivery that emulates the natural system remains unresolved.
Areas covered
Solid Lipid Nanoparticles (SLNs) may provide a solution, because they are nontoxic, biocompatible, and straightforward to formulate thus providing a promising platform for achieving targeted and controlled delivery of various therapeutic agents. This review aims to provide an overview on the suitability and application of SLNs for insulin delivery. A special emphasis is placed on the biopharmaceutical aspects of insulin loaded SLNs which have not been explored in detail to date.
Expert opinion
SLNs have proven to be safe and versatile drug delivery systems suitable for insulin delivery and capable of improving the efficacy and pharmacokinetic profile of encapsulated insulin. There is still some work to be done to fully explore SLNs’ true potential as drug delivery and specifically insulin delivery vehicles suitable for clinical use.
ABSTRACT
Article highlights
Insulin plays a critical role in metabolism modulation including carbohydrate, lipid and protein metabolism.
Goal of achieving optimal insulin delivery that emulates the natural system remains unresolved yet.
An overview of the suitability and application of Solid Lipid Nanoparticles (SLNs) for insulin delivery.
A special emphasis is placed on the biopharmaceutical aspects of insulin loaded SLNs.
SLNs have proven to be safe and versatile drug delivery systems suitable for insulin delivery.
This box summarizes key points contained in the article.
Declaration of interest
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
Reviewer disclosures
Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.