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Review Article

An overview of the efficacy of inhaled curcumin: a new mode of administration for an old molecule

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Received 21 Jul 2023, Accepted 20 May 2024, Accepted author version posted online: 21 May 2024
 
Accepted author version

ABSTRACT

Introduction

Curcumin is a polyphenol with a variety of pharmacological actions. Despite its therapeutic effects and well-known safety profile, the utility of curcumin has been limited due to its deprived physical, chemical, and pharmacokinetic profile resulting from limited solubility, durability, prompt deterioration and pitiable systemic availability. Employment of an amalgamated framework integrating the potential advantages of a nanoscaffold alongside the beneficial traits of inhalational drug delivery system beautifully bringing down the restricting attributes of intended curative interventions and further assures its clinical success.

Areas covered

Current review discussed different application of inhalable nanocurcumin in different medical conditions. Lung diseases have been the prime field in which inhalable nanocurcumin had resulted in significant beneficial effects. Apart from this several lung protective potentials of the inhaled nanocurcumin have been discussed against severe pulmonary disorders such as pulmonary fibrosis, radiation pneumonitis and IUGR induced bronchopulmonary dysplasia. Also, application of the disclosed intervention in the clinical management of COVID-19 and Alzheimer’s Disease has been discussed.

Expert opinion

In this portion, the potential of inhalable nanocurcumin in addressing various medical conditions along with ongoing advancements in nanoencapsulation techniques and the existing challenges in transitioning from pre-clinical models to clinical practice has been summarized.

Disclaimer

As a service to authors and researchers we are providing this version of an accepted manuscript (AM). Copyediting, typesetting, and review of the resulting proofs will be undertaken on this manuscript before final publication of the Version of Record (VoR). During production and pre-press, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal relate to these versions also.

Article highlights

  • Novel delivery systems for nanocurcumin like inhalation offer potential therapeutic opportunities in several pathologies

  • Both in vitro and in vivo results reported the efficiency of nanocurcumin inhalations on primary and metastatic lung cancer

  • Inhalation of nanocurcumin exhibited several types of lung protection like BPD, IPF, neutrophilia, and drug induced toxicity

  • Nanocurcumin aerosolization to the brain can be effective in the treatment of Alzheimer’s disease by enhancing FMeC1 which binds to Aβ -containing plaques in hippocampal and cortex areas

  • Animal studies showed that nanocurcumin inhalation can be effective in Covid-19 and post-Covid complications like PF

Abbreviations

Bleomycin=

BLM

Bronchopulmonary dysplasia=

BPD

Coronavirus disease 2019=

COVID-19

Curcumin powder=

CP

Curcumin=

CUR

Curcumin-loaded mesoporous polydopamine nanoparticles=

CMPN

Idiopathic pulmonary fibrosis=

IPF

Intrauterine growth restriction=

IUGR

Liposomal curcumin dry powder inhaler=

LCD

Low-protein diet=

LPD

Large porous microparticle=

LPMP

Lipopolysaccharide=

LPS

Myeloperoxidase=

MPO

Platelet-derived growth factor=

PDGF

Pulmonary Fibrosis=

PF

Poly lactic-co-glycolic acid=

PLGA

Radiation pneumonitis=

RP

Sprague-Dawley=

SD

Silymarin=

SIL

Declaration of interest

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Reviewer disclosures

Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.

Table 1. Summary of Studies Considered in this Review.

Table 2: Enumeration of different applied for encapsulation of curcumin within nanocarrier

Additional information

Funding

This paper was not funded.

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