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ABSTRACT
Introduction
Curcumin is a polyphenol with a variety of pharmacological actions. Despite its therapeutic effects and well-known safety profile, the utility of curcumin has been limited due to its deprived physical, chemical, and pharmacokinetic profile resulting from limited solubility, durability, prompt deterioration and pitiable systemic availability. Employment of an amalgamated framework integrating the potential advantages of a nanoscaffold alongside the beneficial traits of inhalational drug delivery system beautifully bringing down the restricting attributes of intended curative interventions and further assures its clinical success.
Areas covered
Current review discussed different application of inhalable nanocurcumin in different medical conditions. Lung diseases have been the prime field in which inhalable nanocurcumin had resulted in significant beneficial effects. Apart from this several lung protective potentials of the inhaled nanocurcumin have been discussed against severe pulmonary disorders such as pulmonary fibrosis, radiation pneumonitis and IUGR induced bronchopulmonary dysplasia. Also, application of the disclosed intervention in the clinical management of COVID-19 and Alzheimer’s Disease has been discussed.
Expert opinion
In this portion, the potential of inhalable nanocurcumin in addressing various medical conditions along with ongoing advancements in nanoencapsulation techniques and the existing challenges in transitioning from pre-clinical models to clinical practice has been summarized.
Disclaimer
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Novel delivery systems for nanocurcumin like inhalation offer potential therapeutic opportunities in several pathologies
Both in vitro and in vivo results reported the efficiency of nanocurcumin inhalations on primary and metastatic lung cancer
Inhalation of nanocurcumin exhibited several types of lung protection like BPD, IPF, neutrophilia, and drug induced toxicity
Nanocurcumin aerosolization to the brain can be effective in the treatment of Alzheimer’s disease by enhancing FMeC1 which binds to Aβ -containing plaques in hippocampal and cortex areas
Animal studies showed that nanocurcumin inhalation can be effective in Covid-19 and post-Covid complications like PF
Abbreviations
| Bleomycin | = | BLM |
| Bronchopulmonary dysplasia | = | BPD |
| Coronavirus disease 2019 | = | COVID-19 |
| Curcumin powder | = | CP |
| Curcumin | = | CUR |
| Curcumin-loaded mesoporous polydopamine nanoparticles | = | CMPN |
| Idiopathic pulmonary fibrosis | = | IPF |
| Intrauterine growth restriction | = | IUGR |
| Liposomal curcumin dry powder inhaler | = | LCD |
| Low-protein diet | = | LPD |
| Large porous microparticle | = | LPMP |
| Lipopolysaccharide | = | LPS |
| Myeloperoxidase | = | MPO |
| Platelet-derived growth factor | = | PDGF |
| Pulmonary Fibrosis | = | PF |
| Poly lactic-co-glycolic acid | = | PLGA |
| Radiation pneumonitis | = | RP |
| Sprague-Dawley | = | SD |
| Silymarin | = | SIL |
Declaration of interest
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
Reviewer disclosures
Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.
Table 1. Summary of Studies Considered in this Review.
Table 2: Enumeration of different applied for encapsulation of curcumin within nanocarrier