Ocular biometric repeatability using a new high-resolution swept-source optical coherence tomographer

ABSTRACT

Purpose

To assess the repeatability of ocular biometric parameters using a high-resolution imaging device.

Methods

74 healthy right eyes were included in this study. Five-repeated measurements were taken with ANTERION high-resolution swept-source optical coherence tomographer (SS-OCT) to measure: corneal thickness (central and at 2, 4 and 6-mm diameters), aqueous depth (AD), lens thickness (LT), anterior chamber volume (ACV), axial length (AL), and pupil (diameter and position). The intrasubject standard deviation (S_w), coefficient of repeatability (CoR) and intraclass correlation coefficient (ICC) were calculated. Bland-Altman method was applied to analyze the difference between the first and the last measurement. The average and the difference between both measurements were calculated for all parameters.

Results

We have not found statistically significant differences between repeated measurements (p > 0.05). The mean difference for corneal thickness was between −0.08 and 0.28 μm. For AD and LT was 0.004 and −0.004 μm, respectively. ACV mean difference was −0.03 mm³ and for AL was 0.001 mm. Pupil diameter and position mean differences ranged between −0.008 and 0.009 mm. Overall, most ocular parameters had a S_w <1 and a CoR <2 in their respective units, and an ICC >0.92.

Conclusions

The ANTERION high-resolution SS-OCT device provides good repeatability for different ocular biometric measurements.

KEYWORDS:

• Repeatability
• optical coherence tomography
• biometry
• anterior segment
• ANTERION

Article highlights

• The aim of this study was to evaluate the repeatability of a high-resolution swept-source optical coherence tomographer (ANTERION, Heidelberg Engineering, Inc., Heidelberg, Germany) in 74 healthy subjects aged between 22 and 69 years.

• The coefficient of repeatability and intraclass correlation coefficient were calculated to assess the repeatability. Also Bland-Altman graphical method was applied.

• The results of this study demonstrate that the ANTERION swept-source optical coherence tomographer provides good repeatability for different ocular parameters: corneal thickness, aqueous depth, lens thickness, anterior chamber volume, axial length, and pupil (diameter and position).

Declaration of interest

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

The authors have no proprietary interest in any of the materials mentioned in this article.

Reviewer disclosures

One peer reviewer is a consultant for Zeiss Meditec, and Optopol Technologies. Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.

Additional information

Funding

This paper was not funded.