Assessment of anterior segment measurements using a high-resolution imaging device

ABSTRACT

Purpose

To assess the repeatability of several anterior segment parameters obtained with swept-source optical coherence tomography (SS-OCT).

Methods

We measured 5-times consequently several parameters in 69 eyes using the ANTERION SS-OCT. White-to-white (WTW), angle-to-angle (ATA), spur-to-spur (STS), and lens vault distances were measured in the horizontal- and vertical-meridian. Anterior-chamber-angle (ACA), scleral-spur-angle (SSA), angle-opening-distance (AOD), and trabecular-iris-space-area (TISA) were measured at 500 and 750 μm for the superior-, nasal-,inferior-, and temporal-quadrants. Intrasubject standard deviation (Sw),coefficient of variation (CoV), coefficient of repeatability (CoR), and intraclass-correlation-coefficient (ICC) were calculated for each parameter. Bland-Altman analysis was done.

Results

We have not found statistically significant differences between repeated measurements (p > 0.05). Repeatability was good for the different parameters evaluated. Sw values in distances and areas were low and ranged from 0.01 to 0.07. CoR values showed a similar pattern being larger for those metrics measuring angles. The same happened with CoV values, being very small for WTW,ATA, and STS distances (0.16–0.57%). ICC values for all parameters analyzed were > 0.97. Bland-Altman plots evidenced the narrow limits of agreement for all parameters.

Conclusions

The ANTERION SS-OCT demonstrated high repeatability measuring different distances, angles, and areas of the anterior segment of the eye.

KEYWORDS:

• Repeatability
• optical coherence tomography
• swept source Fourier domain
• ANTERION
• anterior segment

Article highlights

• The purpose of the present study was to evaluate the repeatability of several anterior segment parameters using a high-resolution swept-source optical coherence tomographer (ANTERION, Heidelberg Engineering GmbH, Germany) in 69 healthy subjects.

• Intrasubject standard deviation, coefficients of variation and repeatability, and intraclass correlation coefficient were calculated. Also Bland-Altman graphical method was applied.

• The results of this study show that the ANTERION swept-source optical coherence tomographer provides high repeatability measuring different distances, angles, and areas of the anterior segment of the eye.

Declaration of interest

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Reviewer disclosures

One peer reviewer has acted as a speaker, received honoraria from, and acted as a consultant for Zeiss; and has acted as a speaker and a consultant for Optopol. Peer reviewers on this manuscript have no other relevant financial relationships or otherwise to disclose.

Additional information

Funding

This paper was not funded.