Management of hyperthyroidism in children

ABSTRACT

Introduction: Treatment of hyperthyroidism in children differs according to its etiology; in particular, the optimal therapy of Graves’ disease (GD) remains a matter of debate and there is currently no evidence-based therapeutic strategy that is universally adopted in all the countries.

Areas covered: The most recent treatment strategies in the different pediatric conditions which may be associated with hyperthyroidism. We searched PubMed and Cochrane (1990 to 2016) in order to identify articles to include in this review using the following terms: Hyperthyroidism, Childhood, Antithyroid drug therapy, Thyroidectomy, Radioactive iodine.

Expert commentary: Although pharmacological therapy represents the first-line approach for GD children, we recommend to individualize, as much as possible, the overall therapeutic approach, with no prejudices towards radical therapies, particularly in the cases with frequent relapses. Clinical and laboratory preferential criteria for an individualized therapeutic approach to GD children are given. Treatment procedures for hyperthyroid children without GD are also discussed.

KEYWORDS:

• Fetal and neonatal hypothyroidism
• Graves’ disease
• Hashitoxicosis
• hyperfunctioning thyroid nodules
• McCune Albright syndrome
• methimazole treatment
• radioiodine therapy
• resistance to thyroid hormones
• total thyroidectomy
• TSH-secreting pituitary adenoma

Declaration of interest

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.