ABSTRACT
Introduction
Human T-lymphotropic virus type 1 (HTLV-1) is a lifelong persistent retrovirus associated with numerous systemic and ocular diseases, presenting significant clinical challenges.
Areas covered
A detailed overview of HTLV-1 associated ocular diseases is provided, along with the highlighting of recent findings challenging traditional views on transmission routes and the role of proviral load in HTLV-1 disease onset. The focus is on pathogenesis, clinical presentation, diagnostic approaches, current therapeutic strategies, recent advancements, and potential future directions in treatment.
Expert opinion
Recent discoveries emphasize the crucial role of horizontal transmission in HTLV-1 associated diseases, highlighting the need for heightened global awareness and effective screening practices. It’s revealed that HTLV-1 uveitis onset can be accelerated patients with Graves’ disease, despite a low proviral load and short latency period. Understanding such interplay and the pathogenesis of HTLV-1-associated ocular diseases is important in developing effective treatment strategies. Given the complexities of HTLV-1 ocular diseases, interdisciplinary collaboration is of the essence.
Article highlights
The Human T-Cell Leukemia Virus-1 (HTLV-1) is associated with a wide range of ocular conditions, including HTLV-1 uveitis, keratoconjunctivitis sicca, interstitial keratitis, optic neuritis, overlap syndrome, and Adult T-cell leukemia/lymphoma (ATLL)-related ocular conditions. Each condition presents unique clinical challenges that necessitate an in-depth understanding and tailored treatment strategies for effective management.
Therapeutic strategies for ocular inflammatory diseases related to HTLV-1, including HTLV-1 uveitis, currently focus on suppressing inflammation and controlling symptoms, largely through the use of steroids. This reliance on steroids punctuates the crucial need for new, targeted, and less invasive treatments. While potential solutions such as targeted drugs and biologics offer promising advances, it’s necessary to conduct further research to confirm their effectiveness, assess safety, and validate their use.
The growing recognition of horizontal transmission as a significant route for HTLV-1-associated disease could drive changes in public health interventions. Clinical procedures might also evolve, potentially to include HTLV-1 infection screening for patients with Graves’ disease, and improved guidelines on the use of biologics in HTLV-1 carriers.
ATLL, a severe malignancy caused by HTLV-1, often presents with ocular manifestations. Early detection and appropriate management of ATLL-related ocular symptoms, including those related to leukemia eye infiltration, are critical to improving patient outcomes.
The introduction of allogeneic hematopoietic stem-cell transplantation has improved ATLL treatment and survival, yet it can cause ocular complications such as frosted branch angiitis. Careful monitoring and frequent comprehensive ocular examinations post-transplant are crucial for early detection and treatment.
The importance of robust, context-specific evidence and the need for interdisciplinary collaboration to translate research findings into clinical practice are highlighted. Despite the inherent challenges, continued efforts in research, innovation, and collaboration are essential to bring about substantial improvements in the clinical management of HTLV-1 ocular manifestations.
Declaration of interest
The author has no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript.
Reviewer disclosures
Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.