Abstract
In this article we review the current status of multiple-organ dysfunction syndrome (MODS) in China, with a focus on its epidemiology and pathogenesis and clinical treatment approaches. Current and future research directions are also reviewed with the overall goal of improving our understanding of this disorder so that optimal prevention and treatment strategies can be developed. Pathogenically, Chinese scholars hypothesize that MODS occurs in accordance with a “two-hit” model, which results in an overwhelming systemic inflammatory response within the host. Lipopolysaccharide or endotoxin activates several intracellular signaling pathways via cellular membrane receptors, thereby contributing to this inflammatory response. Supportive therapy of vital organs represents the main therapeutic approach for these patients, although nutritional support in the form of early enteral feeding is also important. Additional approaches include the administration of agents to increase the rate of protein synthesis and modulate the host's immune response. Herbal medicines, together with other traditional Chinese medicines, have also been shown to be effective. With the application of these various therapeutic measures, great progress has been made in the prevention and treatment of MODS in the last 15 years. However, since the 1990s, the mortality due to MODS in China has remained unacceptably high, with little prospect of improvement. Future efforts should focus on more scientific research in this area, with the overall goal of reducing the morbidity and mortality of MODS.