Dear Editor,
I appreciate the comments of Dr Norooznezhad.
I accept that in my review paper there was some missing information that Dr Norooznezhad has corrected. Current literature is so extensive that sometimes you overlook information, such as the one presented by their interesting letter.
The important message of their letter is that IL-1, IL-6, TNF-α, MPP-9, and SDF-1 are involved in the pathogenesis of hemophilic arthropathy.
However, in spite of the reports reviewed by them in their letter and by me in my review article, that highlight the role of angiogenesis in hemophilic arthropathy, it is patent that the role of antiangiogenic drugs in the clinical management of hemophilic arthropathy needs further research.
E. C. Rodriguez-Merchan
Declaration of interest
The author has no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.