The treatment of functional dyspepsia: present and future

ABSTRACT

Introduction

Functional dyspepsia (FD) is a prevalent, but frequently overlooked and/or under diagnosed disorder of gut-brain interaction (DGBI). Functional dyspepsia frequently co-exists with other DGBIs, and persistent symptoms have a significant impact on patients’ quality of life. A variety of therapies (e.g. diet, probiotics, antibiotics, acid suppressants, neuromodulators, prokinetics) are employed to treat the multiple symptoms of FD, although none are uniformly effective.

Areas covered

This review covers currently available therapies for the treatment of FD in addition to novel and emerging therapies that may change the treatment paradigm in the near future. PubMed, Embase and the Cochrane data bank were searched from 1990 to October 2022 for relevant articles.

Expert opinion

Dietary intervention, eradication of H. pylori, and/or a trial of acid suppression are reasonable initial treatment options for patients with FD. Neuromodulators and fundic accommodation agents are underemployed and should be used more routinely by healthcare providers, especially for patients with moderate-severe symptoms. Alternative therapies, such as cognitive behavioral therapy and hypnotherapy, are gaining recognition as safe and effective treatments for FD and can be used alone or in combination with medications. Virtual reality has the potential to significantly improve global FD symptoms.

KEYWORDS:

• Abdominal pain
• dyspepsia
• functional dyspepsia
• neuromodulators
• virtual reality

Article highlights

• Functional dyspepsia (FD) is one of the most common disorders of gut-brain interaction (DGBI).

• FD can be diagnosed with a combination of history, physical examination, limited tests and the use of the Rome IV criteria.

• Dietary interventions may improve symptoms in some patients, but data is limited.

• Medications to improve fundic accommodation should be used more frequently.

• Cognitive behavioral therapy is effective at treating many FD symptoms.

• Virtual reality may improve global FD symptoms and warrants further research.

Declaration of interests

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Reviewer disclosures

Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.

Additional information

Funding

This paper was not funded.