Association of human Hedgehog interacting protein gene polymorphisms with the risk of chronic obstructive pulmonary disease: a meta-analysis

ABSTRACT

Objective

To date, some studies revealed that HHIP gene polymorphisms may be associated with the risk of chronic obstructive pulmonary disease (COPD). Therefore, this meta-analysis explored the association between single-nucleotide polymorphisms (SNPs) of the human hedgehog interacting protein (HHIP) gene and susceptibility to COPD.

Methods

Seven Chinese and English electronic databases were searched for eligible studies up to 30 May 2020. After the inclusion criteria were strictly followed, the Newcastle-Ottawa Scale (NOS) was used to evaluate the quality of the included studies. The pooled odds ratio (OR) of the 95% confidence interval (CI) under four different genetic models was calculated to evaluate the association strength between the SNPs and COPD. Egger’s test was used to evaluate publication bias.

Results

This meta-analysis was registered at PROSPERO (CRD42021235708). In total, 12 studies involving 6623 COPD patients and 11,373 healthy controls were included. Regarding rs13118928 and rs1828591, an A > G mutation increased the risk of COPD in Asian and Caucasian individuals, and the rs13147758 A > G mutation and rs10519717 C > T mutation increased the risk of COPD only in Asian people. No significant publication bias was observed.

Conclusion

This meta-analysis provides a theoretical basis suggesting that HHIP gene polymorphisms may be associated with the risk of COPD.

KEYWORDS:

• Human Hedgehog interacting protein
• genetic polymorphism
• meta-analysis
• single nucleotide polymorphism
• chronic obstructive pulmonary disease

Acknowledgments

We would like to thank American Journal Experts for their assistance with language editing.

Contributions statement

Yi Liao and Yue Liao conceived of and designed the study, acquired and analyzed the data and wrote the manuscript. Fuqiang Wen contributed to the data analysis and manuscript preparation. All authors read and approved the manuscript and agree to be accountable for all aspects of the research in ensuring that the accuracy or integrity of any part of the work is appropriately investigated and resolved.

Declaration of Interests

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Data availability statement

All data generated or analyzed in this study are included in this published article.

Ethical approval

All analyses in the current study were consistent with established medical ethics guidelines.

Informed consent

The current study is based on a publicly available dataset. Thus, informed consent was not needed.

Reviewer disclosures

Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.

Supplemental data

Supplemental data for this article can be accessed https://doi.org/10.1080/17476348.2022.2030226

Additional information

Funding

This study was funded by the 1·3·5 project for disciplines of excellence, West China Hospital, Sichuan University (ZYGD18006 and ZYJC18012).