ABSTRACT
Background
Despite potential benefits and widespread prescription of aspirin among chronic obstructive pulmonary disease (COPD) patients, limited research has investigated its adverse effects (AEs) in COPD population.
Methods
We conducted a retrospective analysis of adverse drug events (ADEs) reported in the US Food and Drug Administration Adverse Event Reporting System (FAERS) between Q1 2013 and Q2 2022. COPD patients were categorized into two groups based on aspirin use. ADEs related to aspirin use were identified using combined reporting odds ratio (ROR), proportional reporting ratio (PRR), information component (IC) methods.
Results
A total of 56,660 ADEs reports associated with COPD patients were included in the study. Among these reports, 144 adverse events were linked to aspirin use in COPD patients, including fatigue (4.12%), diarrhea (3.13%), dyspnea exertional (2.03%), rhinorrhea (1.99%), weight increased (1.89%) and vomiting (1.84%), muscle spasms (1.79%), cardiac disorder (1.74%), heart rate increased (1.69%) and peripheral swelling (1.59%). Subgroup analysis indicates that age and gender might affect the AEs frequency in COPD patients using aspirin.
Conclusions
Our findings identify 10 most frequently reported ADEs associated with aspirin use in COPD patients, thus offer valuable insights into the AEs of aspirin for safer clinical utilization in COPD management.
Author contributions
Xiaohua Li: Formal analysis; Investigation; Validation; Visualization; Writing – original draft. Bin Dai: Data curation; Methodology; Writing – original draft. Qingbing Han: Data curation; Methodology; Writing – original draft. Yanqiu Wu: Conceptualization; Formal analysis; Methodology; Writing – original draft. Bi Ran: Investigation; Software; Validation; Visalization. Tao Wang: Conceptualization; Formal analysis; Investigation; Software. Fuqiang Wen: Funding acquisition; Methodology; Resources; Validation; Visualization; Writing – review & editing. Jun Chen: Funding acquisition; Project administration; Supervision; Writing – review & editing.
Declaration of interest
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
Reviewer disclosures
Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.
Supplementary material
Supplemental data for this article can be accessed online at https://doi.org/10.1080/17476348.2023.2294927