The challenges of pharmacokinetic variability of first-line anti-TB drugs

ABSTRACT

Introduction: Inter-individual variations in the pharmacokinetics (PK) of anti-TB drugs are known to occur, which could have important therapeutic implications in patient management.

Areas covered: We compiled factors responsible for PK variability of anti-TB drugs reported from different settings that would give a better understanding about the challenges of PK variability of anti-TB medications. We searched PubMed data base and Google scholar from 1976 to the present using the key words ‘Pharmacokinetics’, ‘pharmacokinetic variability’, ‘first-line anti-TB therapy’, ‘Rifampicin’, ‘Isoniazid’, ‘Ethambutol’, ‘Pyrazinamide’, ‘food’, ‘nutritional status’, ‘HIV’, ‘diabetes’, ‘genetic polymorphisms’ and ‘pharmacokinetic interactions’. We also included abstracts from scientific meetings and review articles.

Expert commentary: A variety of host and genetic factors can cause inter-individual variations in the PK of anti-TB drugs. PK studies conducted in various settings have adopted different designs, PK sampling time points, drug estimation methodologies. Hence comparison and interpretation of these results should be done with caution More phamacogenomic studies in different patient populations are needed for further understanding.

KEYWORDS:

• First-line anti TB drugs
• interactions
• pharmacokinetics
• tuberculosis
• variability

Declaration of interest

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Additional information

Funding

This paper was not funded.