ABSTRACT
Background
Data on the efficacy of vitamin D in improving the glycemic status of elderly people with prediabetes are scarce. This open-label, randomized-controlled trial investigated the effect of vitamin D supplementation on glycemic markers of Greek people with prediabetes aged 60 years or above, over 12 months.
Research design and methods
Participants were randomized to a weekly vitamin D3 dose of 25,000 IU (n = 45) or nothing (n = 45), on top of lifestyle measures. Anthropometric and glycemic markers were assessed at baseline, 3, 6, and 12 months
Results
Supplemented participants demonstrated a significant increase in 25(OH)D concentrations at 3, 6, and 12 months compared to baseline . In the intervention group, fasting glucose was decreased at 6 months compared to baseline (96.12 ± 5.51 vs 103.40 ± 12.05 mg/dl, p < 0.01) and glycated hemoglobin was significantly lower at 6 and 12 months compared to baseline [5.82 ± 0.21% vs 5.87 ± 0.21%, p = 0.004 and 5.80 ± 0.23% vs 5.87 ± 0.21%, p < 0.001, respectively].
Conclusions
Vitamin D could be complementary to lifestyle change strategy for the management of prediabetes in the elderly.
Clinical trial registration
ISRCTN51643592.
Supplementary material
Supplemental data for this article can be accessed here
Acknowledgments
The authors thank the participants in the present study for their cooperation.
Author contributions
K Kotsa, I Iakovou and A Gotzamani-Psarrakou conceptualized and designed the study. E Zaromytidou, D Drivakou, S Konstantinidou, V Antonopoulou, M Grammatiki and E Manthou collected all data. G Dimakopoulos performed the statistical analysis. E Zaromytidou, T Koufakis, G Dimakopoulos and K Kotsa analyzed and interpreted the results. E Zaromytidou, T Koufakis and G Dimakopoulos performed the literature review and drafted the first version of the manuscript. All authors have read and critically revised the manuscript and approved the final version.
Consent to participate
Written informed consent was obtained from all participants.
Declaration of interest
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
Ethics approval
The research protocol was approved by the Ethics Committee of the Aristotle University of Thessaloniki (approval number: 260/19-04-16).
Reviewer disclosures
Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.
Supplememtary material
Supplemental data for this article can be accessed here