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Acta Clinica Belgica
International Journal of Clinical and Laboratory Medicine
Volume 71, 2016 - Issue 1
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Flow-assisted basophil activation tests in immediate drug hypersensitivity: two decades of Antwerp experience

E. A. MangodtFaculty of Medicine and Health Science, Department of Immunology, Allergology, Rheumatology, University of Antwerp, Antwerp University Hospital, 2610Antwerpen, Belgium
,
A. L. Van GasseFaculty of Medicine and Health Science, Department of Immunology, Allergology, Rheumatology, University of Antwerp, Antwerp University Hospital, 2610Antwerpen, Belgium
,
A. BastiaensenFaculty of Medicine and Health Science, Department of Immunology, Allergology, Rheumatology, University of Antwerp, Antwerp University Hospital, 2610Antwerpen, Belgium
,
I. I. DecuyperFaculty of Medicine and Health Science, Department of Immunology, Allergology, Rheumatology, University of Antwerp, Antwerp University Hospital, 2610Antwerpen, Belgium
,
A. UyttebroekFaculty of Medicine and Health Science, Department of Immunology, Allergology, Rheumatology, University of Antwerp, Antwerp University Hospital, 2610Antwerpen, Belgium
,
M. FaberFaculty of Medicine and Health Science, Department of Immunology, Allergology, Rheumatology, University of Antwerp, Antwerp University Hospital, 2610Antwerpen, Belgium
,
V. SabatoFaculty of Medicine and Health Science, Department of Immunology, Allergology, Rheumatology, University of Antwerp, Antwerp University Hospital, 2610Antwerpen, Belgium
,
C. H. BridtsFaculty of Medicine and Health Science, Department of Immunology, Allergology, Rheumatology, University of Antwerp, Antwerp University Hospital, 2610Antwerpen, Belgium
,
M. M. HagendorensFaculty of Medicine and Health Science, Department of Pediatrics, University of Antwerp, Antwerp University Hospital, 2610Antwerpen, Belgium
,
L. S. De ClerckFaculty of Medicine and Health Science, Department of Immunology, Allergology, Rheumatology, University of Antwerp, Antwerp University Hospital, 2610Antwerpen, Belgium
&
D. G. EboFaculty of Medicine and Health Science, Department of Immunology, Allergology, Rheumatology, University of Antwerp, Antwerp University Hospital, 2610Antwerpen, BelgiumCorrespondence[email protected]
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Pages 19-25 | Published online: 07 Feb 2016
 
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Abstract

The last two decades have witnessed that flow-assisted analysis of in vitro-activated basophils can constitute a valuable adjunct in the in vitro diagnostic approach of immediate drug hypersensitivity reactions (IDHR). This article summarises the current experience with the basophil activation test in the diagnosis of IDHR, with particular focus on allergy to curarising neuromuscular blocking agents, antibiotics (β-lactams and fluoroquinolones), iodinated radiocontrast media and opiates.

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