Three cases of OXA-48-like carbapenemase producing Enterobacteriaceae (not) detected using Xpert^® Carba-R

Abstract

The increasing prevalence of carbapenemase-producing Enterobacteriaceae necessitates laboratories to invest in the detection of these bacteria, both with phenotypic and to a lesser extent molecular methods. OXA-48-like strains are rapidly emerging, especially in Europe. Since the expression level of OXA-48 is low and some strains present with several alleles, some types might be missed by some molecular assays. Three cases of OXA-48-like strains are described here, where the detection was not straightforward.

Keywords:

• CPE
• OXA-48-like
• laboratory confirmation

Acknowledgements

Special thanks to Prof. Y. Glupczynski and Dr T.-D. Huang for performing amplicon sequencing and for critical review of this manuscript.