Statin-induced necrotizing autoimmune myopathy (SINAM): case report and review of the literature

ABSTRACT

Statins are a well-known and highly effective treatment for hypercholesterolemia in order to prevent cardiovascular disease. Occasionally, patients may experience muscle-related events such as myalgia or muscle cramps. Recently, SINAM (statin-induced necrotizing autoimmune myopathy) has been described in patients using statins. Although very uncommon, it may cause a life-threatening situation associated with rhabdomyolysis. We present a case concerning a 71-year-old woman who presented with muscle fatigue for several weeks. Statin therapy was discontinued but symptoms did not resolve. Further workup led to a diagnosis of SINAM for which treatment with immunosuppressants was started.

KEYWORDS:

• Statin
• 3-hydroxy-3-methylglutaryl-coenzyme a reductase
• SINAM
• myopathy

Disclosure statement

No potential conflict of interest was reported by the author(s).