Pesticide-Induced Scleroderma and Early Intensive Immunosuppressive Treatment

ABSTRACT

The authors report 2 children with generalized cutaneous sclerosis exposed to pesticides containing malathion and diniconazole. Treatment with immunosuppressives resulted in partial improvement in the cutaneous signs, particularly over the face, trunk, and proximal limbs. The considerable exposure to chemicals related with the initiation of symptoms and absence of organ involvement suggested a diagnosis of chemically induced scleroderma-like disorder. Although autoantibodies were negative, previously reported relevant associations of anti-kinetochore and anti-topoisomerase function of active ingredients—diniconazole and phosphorodithioate—and solvents of these pesticides are also discussed. Careful follow-up for systemic involvement is warranted, since these agents may have triggered systemic scleroderma in these patients. Elimination of chemical exposure of children is stressed.

KEYWORDS:

• anti-kinetochore
• anti-topoisomerase
• children
• dichlorophenyl
• dimethyl ethyl
• diniconazole
• malathion
• pesticide
• phosphorodithioate
• scleroderma