Selenium, oxidative stress and inflammatory markers in handicraft workers occupationally exposed to lead

Abstract

Occupational Lead (Pb) exposure increases reactive oxygen species and has been reported to impact inflammatory response by modulating intracellular signaling pathways. Selenium (Se) a vital component of the antioxidant system that plays an important role in modulating cytokines. The present study evaluated Se, malondialdehyde (MDA), total antioxidant capacity (TAC) and cytokines (IL-6, TNF-α, IL-10, IL-17a) in 81 Pb exposed male workers. The median (range) of blood lead level (BLL) and Se were 5 (0.50–31.76) µg/dL and 104 (46.9–189.6) µg/L respectively. The Se, TAC levels were decreased, and MDA, IL-6 levels were increased in the high Pb group (>5μg/dL). Blood lead level independently predicted oxidative stress and antioxidant status. Selenium, TAC levels negatively and MDA, IL-6 levels positively correlated with BLL. Association of Se with IL-6 and TAC suggests some probable role of Se in the underlined mechanism of Pb toxicity.

Keywords:

• Cytokines
• inflammation
• lead
• oxidative stress
• selenium