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Chimerism Volume 6, 2015 - Issue 1-2: Ray Owen Centennial
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Review

Stable mixed chimerism and tolerance to human organ transplants

Samuel StroberDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, USACorrespondence[email protected]
Pages 27-32 | Received 06 Aug 2015, Accepted 27 Oct 2015, Published online: 08 Feb 2016
 
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ABSTRACT

Tolerance to combined kidney and hematopoietic cell transplant has been achieved in humans after establishment of mixed chimerism allowing for the withdrawal of immunosuppressive drugs. The seminal contributions of Ray Owen provided the scientific basis for the human protocol.

Disclosure of potential conflicts of interest

No potential conflicts of interest were disclosed.

Funding

Research on clinical tolerance at Stanford was supported by a grant (5 PO1 HL075462) from the National Heart, Lung and Blood Institute.

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