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Journal of Dietary Supplements Volume 6, 2009 - Issue 3
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Original

Identification of Marker Genes for Lipid-Lowering Effect of a Short-Chain Fructooligosaccharide by DNA Microarray Analysis

Tomoyuki Fukasawa Food and Health R&D Laboratories, Meiji Seika Kaisha, Ltd., Chiyoda, Sakado-shi, Saitama, JapanCorrespondence[email protected]
,
Koichiro Murashima Food and Health R&D Laboratories, Meiji Seika Kaisha, Ltd., Chiyoda, Sakado-shi, Saitama, Japan
,
Tomoko Nemoto ILSI Japan-Endowed Chair of Functional Food Science and Nutrigenomics, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi, Bunkyo-ku, Tokyo, Japan
,
Ichiro Matsumoto ILSI Japan-Endowed Chair of Functional Food Science and Nutrigenomics, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi, Bunkyo-ku, Tokyo, Japan
,
Jinichiro Koga Food and Health R&D Laboratories, Meiji Seika Kaisha, Ltd., Chiyoda, Sakado-shi, Saitama, Japan
,
Hidetoshi Kubota Food and Health R&D Laboratories, Meiji Seika Kaisha, Ltd., Chiyoda, Sakado-shi, Saitama, Japan
&
Minoru Kanegae Food and Health R&D Laboratories, Meiji Seika Kaisha, Ltd., Chiyoda, Sakado-shi, Saitama, Japan
 show all
Pages 254-262 | Published online: 09 Sep 2009
 
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Abstract

Administration of short-chain fructooligosaccharide (scFOS) is known to lower serum triglyceride levels in rats fed a high-fat diet, but the molecular mechanisms remain unclear. This study aimed to identify marker genes for lipid-lowering effect of scFOS administration. The changes in hepatic gene expressions in rats fed scFOS were investigated using DNA microarray and quantitative RT-PCR analysis. The DNA microarray showed that phytanoyl-CoA 2-hydroxylase 2 (Phyh2), lipoprotein lipase (Lpl) and tyrosine aminotransferase (Tat) were significantly affected by scFOS administration (p < .05). Since Lpl is involved in lipid metabolism, the up-regulation of Lpl in the liver can be a potential marker of the lipid-lowering effect of scFOS.

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