A Randomized, Double-Blind, Placebo-Controlled Trial to Determine the Effectiveness and Safety of a Thermogenic Supplement in Addition to an Energy-Restricted Diet in Apparently Healthy Females

ABSTRACT

The increasing interest in weight loss has seen a concurrent rise in the supplemental use of thermogenics to aid weight loss efforts. To date, the effectiveness and safety of supplemental proprietary blend thermogenics, in conjunction with high-protein energy-restricted diets have not been thoroughly evaluated. The purpose of this study was to investigate the efficacy of a low-calorie, high-protein diet with and without the concomitant use of a thermogenic supplement on body weight and body composition in apparently healthy females. Subjects were divided into three groups, Bizzy Diet+FitMiss Burn (BURN, N = 12), Bizzy Diet+Placebo (PLA, N = 13), and Control (CON, N = 14), and underwent two testing sessions separated by approximately 3 weeks. Resting blood pressure (BP), resting heart rate (RHR), clinical safety markers, body weight (BW), and body composition were assessed during each testing session. Repeated measures analysis of variance (ANOVA) revealed a significant effect for time relative to BW, total body fat mass (FM), leg FM, and trunk FM. Post hoc analysis revealed that the BURN and PLA groups experienced significant decreases in both BW and total body FM compared to CON (p <.05). There were no significant interactions for BP, RHR, or clinical safety markers over the course of the study. The Bizzy Diet, both with and without the addition of FitMiss Burn thermogenic, appears to be safe for short-term use and may lead to greater improvement in body composition and BW in an apparently healthy female population.

KEYWORDS:

• body composition
• body fat
• nutrition
• supplementation
• weight loss

Acknowledgments

The authors would like to recognize and thank the late Dr. Travis Beck (University of Oklahoma) for his statistical guidance and commitment to supporting and mentoring students and aspiring scientists. He will be forever missed.

Declaration of Interest

Jordan R. Moon was an employee of the funding source during the time of study design and data collection. Otherwise, all authors have declared no competing interests or financial interests concerning the outcome of this investigation.

Funding

The authors thank MusclePharm Corporation for supplying the products and funding the investigation. MusclePharm Corporation is the producer of both the Bizzy Diet and the FitMiss Burn supplement.

About the authors

Kristina L. Kendall holds a PhD in exercise physiology and currently serves as the science editor for Bodybuilding.com.

Parker N. Hyde holds an MS in exercise science and is currently a doctoral student in the department of human sciences at The Ohio State University.

Ciaran M. Fairman holds an MS in exercise science and is currently a doctoral student in the department of human sciences at The Ohio State University.

Kaitlyn M. Hollaway holds an MEd in exercise science and is currently a clinical research manager in the clinical trials unit at the University of Kansas Medical Center - Wichita campus.

Petey W. Mumford holds an MEd in exercise science and is currently a doctoral student in the school of kinesiology at Auburn University in the molecular and applied sciences laboratory.

Cody T. Haun holds an MA in exercise science and is currently a doctoral student in the school of kinesiology at Auburn University in the molecular and applied sciences laboratory.

Brooks Mobley holds an MEd in exercise science and is a doctoral candidate in the school of kinesiology at Auburn University in the molecular and applied sciences laboratory.

Wesley C. Kephart holds an MS in kinesiology and is currently a doctoral candidate in the school of kinesiology at Auburn University in the molecular and applied sciences laboratory.

Aaron C. Tribby holds an MEd in exercise science and currently works in the health and wellness division of Mercy Hospital in Springfield, MO.

Dylan Kimber holds a BS in exercise science from Metropolitan State University.

Jordan R. Moon holds a PhD in exercise physiology and currently serves as the executive director of research and education for Impedimed Inc. He also serves as a faculty member for the United States Sports Academy, Concordia University Chicago, American Public University, and American Military University.

Darren T. Beck is an assistant professor in the department of cell biology and physiology at the Edward Via College of Osteopathic Medicine - Auburn Campus and serves as an associate director of the molecular and applied sciences laboratory in the school of kinesiology at Auburn University.

Michael D. Roberts is an associate professor in the school of kinesiology at Auburn University where he directs the molecular and applied sciences laboratory.

Kaelin C. Young is an assistant professor in the department of cell biology and physiology at the Edward Via College of Osteopathic Medicine - Auburn Campus and serves as an associate director of the molecular and applied sciences laboratory in the school of kinesiology at Auburn University.