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ABSTRACT
This study investigated the effect of Aloe vera in diabetes-induced nephropathy in rats. As diabetes-associated hyperlipidemia and oxidative stress have been implicated in the pathogenesis of diabetic nephropathy, we evaluated the protective effect of whole leaf extract of Aloe vera on the basis of its hypolipidemic and antioxidative property. Aloe vera (300 mg/kg orally) has been noted to possess renoprotective effect in experimental diabetic nephropathy. However, its mechanism is not fully understood. Rats were administered streptozotocin (STZ) (55 mg/kg intraperitoneally once) to induce experimental diabetes mellitus. The development of diabetic nephropathy was assessed biochemically and histologically. In addition, the diabetes-induced lipid profile and renal oxidative stress were assessed. The single administration of STZ produced diabetes, which induced renal oxidative stress, altered the lipid profile, and subsequently produced nephropathy in eight weeks by increasing serum creatinine, blood urea nitrogen, proteinuria, and glomerular damage. Treatment with Aloe vera (300 mg/kg/day orally) was noted to be more effective against the diabetes-induced nephropathy and renal oxidative stress as compared to lisinopril (1 mg/kg/day orally), a reference agent. It may be concluded that diabetes-induced oxidative stress and lipid alterations may be accountable for the induction of nephropathy in diabetic rats. The treatment with Aloe vera (300 mg/kg/day orally) may have prevented the development of diabetes-induced nephropathy by reducing lipid alteration, decreasing renal oxidative stress, and providing direct renoprotective action.
Declaration of interest
The authors declare no conflicts of interest. The authors alone are responsible for the content and writing of the article.
Acknowledgment
The authors express their gratitude to Prof. (Dr.) Jagannath Sahoo, Principal, KIET School of Pharmacy, Ghaziabad, Uttar Pradesh, India, and Sunpure Research and Incubation Centre, Sunpure Extracts Pvt. Ltd, Sunpure House Delhi, India, for his inspiration and constant support for this study.
Additional information
Notes on contributors
Mandeep Kumar Arora
Mandeep Kumar Arora, M. Pharm (Pharmacology), Ph.D, Associate Professor, Department of Pharmacology KIET School of Pharmacy, Ghaziabad Research interest- Vascular Pharmacology.
Yogesh Sarup
Yogesh Sarup, M. Pharm (Pharmacology) Research Scholar, Department of Pharmacology KIET School of Pharmacy, Ghaziabad Research interest- Cardiovascular Pharmacology.
Ritu Tomar
Ritu Tomar, M. Pharm (Pharmacognosy) Associate Professor, Department of Pharmacognosy Swami Vivekanand Subharti University, Meerut Research interest- Ethnopharmacology.
Mary Singh
Mary Singh, M. Pharm (Pharmacology) Research Scholar, Department of Pharmacology KIET School of Pharmacy, Ghaziabad Research interest- Cardiovascular Pharmacology.
Puspendra Kumar
Puspendra Kumar, M.Pharm (Pharmacognosy), Ph.D Associate Professor, KIET School of Pharmacy, Ghaziabad Research interest- Ethnopharmacology.