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Abstract
Oxidative stress plays an important role in the pathogenesis of Parkinson’s disease (PD), particularly the inhibition of mitochondrial complex-I. This study aimed to evaluate the effect of fisetin in the rotenone-induced rat model of PD. Rotenone was administered (2 mg/kg s.c.) for 35 days to induce PD in animals. Fisetin was administered at two doses (10 mg/kg and 20 mg/kg p.o.) for 25 days to the animals that were given rotenone. Behavioral experiment, i.e. cylinder test, was performed to assess the motor asymmetry. Animals were euthanized, and mid brains were isolated for the estimation of tricarboxylic acid cycle enzymes, oxidative measures (lipid peroxidation (LPO), glutathione (GSH) and catalase) and complex-I activity. In addition, histopathological studies were conducted. Fisetin treatment improved motor function in the cylinder test and reversed the rotenone-induced changes in mitochondrial enzymes, striatal dopamine levels, antioxidant enzyme levels and histological changes. An important finding of this study was both the doses of fisetin significantly (p < 0.05) enhanced rotenone-induced behavioral and biochemical changes and the effects were found to be dose dependent. Based on the present results, we hypothesize that fisetin may improve the mitochondrial enzyme activity, thereby preventing the pathogenesis of PD.
Declaration of interest
The authors declare that they have no conflict of interest.
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Notes on contributors
Kanakalatha Alikatte
Kanakalatha Alikatte, M Pharm, Assistant professor, Department of Pharmacology, St. Peters institute of pharmaceutical Sciences, Pursuing PhD in Osmania University, Hyderabad, India.
Suresh Palle
Suresh Palle, M Pharm, PhD, Associate professor, Department of Pharmacology, Vaagdevi Institute of Pharmaceutical Sciences, Kakatiya University, Warangal, India.
Jadi Rajendra Kumar
Jadi Rajendra Kumar, M Pharm, Assistant professor, Department of Pharmaceutics, Anurag Group of Institutions, School of Pharmacy, Pursuing PhD in Osmania University, Hyderabad, India.
Naveen Pathakala
Naveen Pathakala, M Pharm, Assistant professor, Department of Pharmacology, Anurag Group of Institutions, School of Pharmacy, Pursuing PhD in Osmania University, Hyderabad, India.