https://orcid.org/0000-0002-8996-8610
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Abstract
Acute renal failure (ARF) has been documented as a life-threatening disease with high morbidity and mortality. We investigated the protective effect of Luteolin against ARF. In this study, forty-male Wistar albino rats were randomly divided into four groups (n = 10). Group A received normal saline. Group B received glycerol (10 ml/kg BW, 50% v/v in sterile saline, i.m.). Groups C and D were pretreated with Luteolin 100 and 200 mg/kg for 7 days, and thereafter administered Glycerol (10 ml/kg BW, 50% v/v in sterile saline, i.m.). Administration of glycerol significantly increased systolic blood pressure, diastolic blood pressure and mean arterial pressure. Renal protein carbonyl and xanthine oxidase increased significantly while significant reduction in the activity of renal glutathione peroxidase, glutathione S-transferase and glutathione reductase was observed in the glycerol intoxicated rats. Furthermore, administration of glycerol led to significant increases in serum creatinine and blood urea nitrogen together with reduction in nitric oxide (NO) bioavailability. Immunohistochemistry revealed that glycerol intoxication enhanced expressions of kidney injury molecule 1, nuclear factor kappa beta and cardiac troponin (CTnI). However, Luteolin pretreatment normalized blood pressure, reduced markers of oxidative stress, renal damage, and improved NO bioavailability. Luteolin also downregulated the expressions of kidney injury molecule 1, nuclear factor kappa beta and cardiac troponin. Together, Luteolin might open a novel therapeutic window for the treatment of acute renal failure and cardiac complication.
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The authors declare no conflict of interest whatsoever.
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Notes on contributors
Ademola Adetokunbo Oyagbemi
Ademola Adetokunbo Oyagbemi is a Senior Lecturer at the Department of Veterinary Physiology and Biochemistry, and a Consultant to the Veterinary Teaching Hospital, Faculty of Veterinary Medicine, University of Ibadan, Nigeria. He has Doctor of Veterinary Medicine with master’s degrees in both Pharmacology and Biochemistry, and Ph.D. in Biochemistry. In addition, He is a Fellow of College of Veterinary Surgeons, Nigeria (FCVSN). His research interest focuses on the Cardiovascular Pharmacology, Neuropharmacology and Toxicology. In his laboratory, he explores the use of medicinal plants and phytochemicals/ nutraceuticals in ameliorating, mitigating or reversing cardiovascular diseases such as hypertension, diabetes, neurodegenerative conditions including Parkinson disease e.t.c. Over the years, he has attempted to explore canonical and non-canonical pathways associated with inflammation, cell survival, apoptosis, and antioxidant defence system both in vitro and in vivo. From these past studies, has used different signaling pathways as molecular tools and therapeutic targets in the treatment or modulation of different cardiovascular and neurodegenerative conditions. Some of these signaling pathways he has explored include mineralocorticoid receptor, angiotensin converting enzyme, kidney injury molecule, glial fibrillary acidic protein (GFAP), nuclear factor erythroid 2-related factor 2 (Nrf2), nuclear factor kappa beta, p38MAPK,COX-2/Bax, HSP70, ERK, and PPARγ.
Olumuyiwa Abiola Adejumobi
Dr. Olumuyiwa Abiola Adejumobi is a veterinarian and researcher in the University of Ibadan. He is a member of Cardio-renal laboratory, University of Ibadan. He joined the service of the University of Ibadan as Veterinary Registrar in the Veterinary Teaching Hospital (November 2011- November 2012) and later as the Academic staff and Registrar in Small Animal and Laboratory Animals Unit of the Department of Veterinary Medicine, University of Ibadan (2012 till date). He became a Fellow of the College of Veterinary Surgeons (FCVSN), Nigeria in 2018. He belongs to national and international societies including American Society of Pharmacology and Experimental Therapeutics (ASPET), USA, Physiological society (PHYSOC), UK, Society of Medicinal Plants for Economic Development (SOMPED), Africa, Society of Toxicology (SOT), USA. He has publications in local and international peer-reviewed journals. His research interest focuses on cardiovascular pharmacology and internal medicine using medicinal plants and phytochemicals as novel therapeutic agents and their molecular mechanisms of action.
Temitayo Olabisi Ajibade
Dr. Temitayo Olabisi Ajibade DVM, with Ph.D. in Veterinary Physiology, and Fellow of the College of Veterinary Surgeons (FCVSN). He teaches veterinary Physiology to undergraduate veterinary students at the Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ibadan. He is Registrar at the Veterinary Teaching Hospital (VTH) and Sub-dean Undergraduate, Faculty of Veterinary Medicine, University of Ibadan. He belongs to national and international societies including American Society of Medicinal Plants for Economic Development (SOMPED), Africa, Society of Toxicology (SOT), USA, America Physiological Society (APS), USA, Physiological society (PHYSOC), UK. He has publications in highly-rated international peer-reviewed journals. Dr Ajibade’s research interest is in the areas of Cardiovascular and Reproductive Physiology.
Ebunoluwa Racheal Asenuga
Ebunoluwa Racheal Asenuga holds Doctor of Veterinary Medicine and MSc (Biochemistry) degrees. She is a Lecturer at the Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Benin, Benin City, Nigeria. Most of her research activities focus on environmental toxicology, where she looks at the effect of environment toxicants on some systems of the body such as the cardiovascular system, reproductive system e.t.c., as well as using nutraceuticals and medicinal plants to prevent or alleviate the detrimental effects of these environmental toxicants. Recently, she has been looking into the world of endocrine disruptors, their effect in the aquatic environment and the possibilities of bioremediation as a technique to clean up the aquatic bodies.
Jeremiah Moyinoluwa Afolabi
Jeremiah Afolabi is a pre-doctoral fellow in the Molecular and Translational Physiology Ph.D. track at the University of Tennessee Health Science center, Memphis, USA. He holds DVM and MVSc. degrees from the University of Ibadan, Nigeria. His current research focuses on the mechanisms that underlie acute and chronic kidney disease using small and large preclinical animal models.
Blessing Seun Ogunpolu
Blessing Seun ogunpolu is a veterinary surgeon with a passion for translational biomedical research. She works as a Research Assistant at the Cardio-renal research group, Faculty of Veterinary Medicine, University of Ibadan. Dr. Ogunpolu won 2020 International Travel Award to present her research findings at ASPET conference, USA. An avid birdwatcher with interest in ecosystem conservation.
Olufunke Olubunmi Falayi
Olufunke Olubunmi Falayi is a graduate student in the Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary medicine, University of Ibadan, Nigeria. She holds a Doctor of Veterinary Medicine and a Masters’ degree in Veterinary Pharmacology and Toxicology, both from the University of Ibadan, Nigeria. She works as a Research Assistant at the Cardiorenal Laboratory, a biomedical laboratory that focuses on non-infectious diseases of various body systems including the cardiovascular, renal and nervous systems. She utilizes techniques such as redox and inflammation-based assays, immunohistochemistry and immuno-blotting and has collaborated on several projects in drug discovery, development and innovation against hypertension and related cardiovascular and renal diseases. Using animal models, she has explored the therapeutic effects of various medicinal plants, plant-derived products and phytochemicals on diseases such as hypertension, myocardial infarction, diabetes, acute renal injury among others, and the signaling pathways involved in the pathogenesis and amelioration of these diseases.
Fasilat Oluwakemi Hassan
Fasilat Oluwakemi Hassan is a graduate of Veterinary Medicine (DVM) from the University of Ibadan, I earned a Master’s degree in Veterinary Biochemistry also from the prestigious university of Ibadan. She is a Research Assistant at the cardio-Renal Research Laboratory, University of Ibadan, and also an aspiring Ph.D. candidate. She has been involved with research activities, deciphering certain mechanisms involved in disease progression especially those associated with the cardiovascular system including hypertension, cardiac arrhythmia, heart failure, and other disease conditions affecting the nervous system. She has been carrying out research to understand the signaling pathways through which Extracellular Regulated Kinase (ERK), Caspase 3 and 9, nuclear erythroid factor related-factor 2 (Nrf2), nuclear factor Kappa beta (NF-κB) activities involved in various disease conditions. She is a member of Society of Toxicology (SOT), USA, Physiological society (PHYSOC), UK, American Society of Pharmacology and Experimental Therapeutics (ASPET), USA, Society of Medicinal Plants for Economic Development (SOMPED), Africa. She desires to dedicate her lifelong research career for development of more effective therapeutics for human and animal healthcare.
Enivwenaye Williams Nabofa
Enivwenaye E.W. Nabofa, BSc. MSc., PhD, is an early career scientist. He presently serves as a faculty at the Physiology Department, School of Basic Medical Sciences, Benjamin S. Carson College of Medicine, Babcock University, Ogun State, Nigeria. He is a cardiovascular physiologist with research interest in cardiovascular and metabolic studies, using nanotechnology and plant cyclotides in the possible treatment and or prevention of cardiovascular and metabolic disorders. He is a member of several learned associations such as Physiological Society of Nigeria (PSN), Physiological Society of UK (PHYSOC), British Pharmacology Society (BPS), Society for Endocrinology (SfE), Society for Medicinal Plants and Economic Development (SOMPED).
Temidayo Olutayo Omobowale
Dr. Temidayo Olutayo Omobowale holds D.V.M (1995), M.Vet.Sci (2003), and Ph.D. (2011) from the University of Ibadan, and FCVSN (2013). He is a Senior Lecturer and currently the head of department of Veterinary Medicine, Department of Veterinary Medicine at the University of Ibadan, Nigeria with focus on Veterinary Internal Medicine. Also, he is consultant to the Veterinary Teaching Hospital, University of Ibadan, Nigeria. He is a member of several professional and scientific organizations including the Nigerian Veterinary Medical Association, The Physiological Society, the Society of Toxicology and the British Small Animal Veterinary Association. Dr. Omobowale and his research team have been working on the use of natural products commonly available in Nigeria for the management of cardiovascular, renal and metabolic diseases using experimental models. He is a member of Society of Toxicology (SOT), USA, Physiological society (PHYSOC), UK, American Society of Pharmacology and Experimental Therapeutics (ASPET), USA.
Olufunke Eunice Ola-Davies
Olufunke Eunice Ola-Davies is a Professor of Veterinary Biochemistry in the Environmental Toxicology, Phytomedicine and Cancer Research Unit. She obtained Doctor of Veterinary Medicine degree, Master’s Degrees in Veterinary Parasitology and Biochemistry, and a doctoral degree in Biochemistry. Professor Ola-Davies is one of the leading scientists of toxicology in the University of Ibadan, and in recognition of her active role in this field, she was honored with the Global Senior Scholar exchange programme award (GSSEP) of the Society of Toxicology, USA (2017). She is the recipient of many national and international awards amongst which are Postgraduate Training Fellowship of the Third World Organization for Women in Science (2002), Norman E. Borlaug Fellowship (USA), John D. and Catherine T. MacArthur Foundation Overseas Training Research Fellowship (USA), IUTOX/AstraZeneca/SOT Endowment Fund award (2014), World Academy of Science -UNESCO (2015-2018) e.t.c. She is a fellow of the College of Veterinary Surgeons Nigeria (FCVSN). Prof Olufunke Ola-Davies is a visiting professor at Oregon State University, USA, University of Forte Hare, Alice, South Africa and Norwegian University of Science and Technology (NTNU), Trondheim. She is currently an external examiner in some Universities within and outside Nigeria and a member of Senate of the University of Ibadan.
Adebowale Benard Saba
Adebowale Bernard Saba is a Doctor of Veterinary Medicine, with Masters and Ph.D. degrees in Veterinary Pharmacology and Toxicology. He is a Professor of Veterinary Pharmacology and Toxicology. He teaches veterinary pharmacology and toxicology to undergraduate and postgraduate students. He is also currently the Chair of the department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Ibadan. His research focus has been on the toxicology of various drugs, heavy metals, environmental pollutants/toxicant and plants that are of medicinal use. He has investigated the antioxidant, anti-inflammatory, analgesic, antihypertensive effects of various medicinal plants and phytochemicals, together with the elucidation of mechanism(s) of action. He is a member of various professional bodies including society of toxicology (SOT), USA, Forum of Nigeria Toxicologists (FONTOX), Toxicology of African origin (TAO), West Africa Society of Pharmacology, among others.
Adeolu Alex Adedapo
Professor Adeolu Alex Adedapo, DVM, MSc, PhD FIIA FACN is of the Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Ibadan, Nigeria. He has additional specialist training in the role of biotechnology in Medicinal Plants at the International Institute of Tropical Agriculture, Ibadan, Nigeria (2003), Advanced Leadership Training at the Haggai Institute of Leadership, Singapore (2007, Advanced Training in Renal pathophysiology techniques at the Center of Cardiovascular Diseases, Texas Southern University, Houston, TX, USA (2009-2010) and IUTOX training on environmental risk analysis with focus on water, air quality and hazardous chemical wastes in 2012. He has published in both national and international journals with over 180 publications to his credit. He is a recipient of Bassir-Thomas Biomedical Foundation award (1998); OMPADEC postgraduate award (2000); National Research Foundation of South Africa (2006-2007); UNESCO award (2008); Senior Fulbright Scholarship (2009-2010); International Union of Toxicology award (2012); University revitalization grant (2015); TETFUND NRF (2015) and many national and global conference travel supports.
Oluwafemi Omoniyi Oguntibeju
Oluwafemi Omoniyi Oguntibeju is Professor of Biomedical Science and Group Leader (Phytomedicine & Phytochemistry Group), Department of Biomedical Sciences, Cape Peninsula University of Technology, Bellville, Cape Town, South Africa. Over the years, He has been involved in the field of HIV/AIDS and related- public health issues but later on natural products and health (Phytomedicine). He has successfully supervised 20 honours’ projects, 25 masters and 7 doctoral students, 3 postdoctoral research fellows and currently supervising 6 doctoral and 6 masters’ students at various stages of their programmes. He has published over 160 scientific articles in peer-review journals, 20 chapters in books, editor of three books on diabetes, presented over 70 papers at international and national conferences. He is a member of editorial board of various scientific journals and reviews manuscripts for various scientific journals. Professor Oguntibeju has received various awards such as the Gold and Platinum Research Excellence Awards at his current university. He is a National Research Foundation (NRF) C-rated researcher and hold Postgraduate Diploma (FIMLS) of the Institute of Medical Laboratory Science, Nigeria in Clinical Biochemistry, MSc degree in Biochemistry from the University of Ibadan and doctoral degree in Biomedical Science, Central University of Technology, Free State (2005), South Africa.
Momoh Audu Yakubu
Momoh Audu Yakubu, PhD, Tenured Professor of Pharmacology and Environmental Toxicology in the Department of Environmental and Interdisciplinary Sciences, a Senior Scientist and Head of Vascular Biology Unit of the Center for Cardiovascular Diseases, Professor of Pharmaceutical & Environmental Health Sciences, College of Pharmacy and Health Sciences, Texas Southern University, Houston - Texas. Dr. Yakubu employs interdisciplinary research approach integrating environmental, biological, pharmacological and toxicological analysis to meet the challenges of integrated medical and environmental concerns. His research is synergized by integrated analysis using of instruments such as – Seahorse XFp for evaluation of energy metabolism and regulation of variety of cellular and physiological processes in metabolic dysfunction/ or reprogramming of cells. Profiling and analysis of emerging contaminants; Analysis and Molecular consequences of exposure to complex chemical mixtures; Profiling of gut and saliva of trypanosomes’ infected tsetse fly for differentially regulated proteins, peptides, and lipids, the role of gasotransmitters – NO, CO, and H2S as neuroprotectants in stroke or traumatic brain injury. Funding: Dr. Yakubu’s research had attracted funding from Carnegie Foundation, NIH, AHA, and others with a recent collaborative (with mentees from the University of Ibadan) award from UK based - World Small Animal Veterinary Association.