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Systems Biology in Reproductive Medicine (SBiRM) publishes work on human, animal, and other model systems. The synergy of embracing science, agriculture, and medicine in our scope informs and bolsters our emphasis on the male and female contribution to the birth and health of the child. Our systems approach framework benefits and advances Personalized and Precision Reproductive Medicine. We continue to receive Reviews and Hypotheses that provide researchers the opportunity to present a new idea highlighting preliminary data that can accelerate advances in the field.

As we continue to move publishing in science and medicine forward, we are conscious of the aura of AI that impacts all of our lives. The presence of AI in peer-reviewed publishing is recognized and policies are in place by the publisher to ensure its appropriate use and documentation. This phenomenon will no doubt increase in sophistication. We are committed to, and it is critical that we, pursue a clear and informed approach to the integrity of research, authorship, the review process, and publication.

Our dedicated Editorial Board reflects the interests and breadth of developments in the field. We are pleased to welcome new Editorial Board member, Professor Marco G. Alves, PhD, Department of Medical Sciences, University of Aveiro, Portugal who brings expertise in bioinformatics and statistics. We look forward to the participation of Dr. Alves on the Editorial Board.

Beginning this year, 2024, SBiRM is available as an online only format. We will next transition to an Open Access publication.

We are pleased to announce that the cover figure selected for 2024 Volume 70 is from Panel C of Figure 5 – The presence of polyamines decreases the [cAMP]i and the molecular docking suggest an interaction between sAC and the polyamines from ‘Polyamines modulate mouse sperm motility’ by Lorena Rodrıguez-Paez, Charmina Aguirre-Alvarado, German Chamorro-Cevallos, Alcantara-Farfan Veronica, Calderon-Espinosa Sandra Irel, Castillo-Perez Hugo, Carlos Armando Garcıa-Perez, Guadalupe Elizabeth Jim enez-Gutierrez, and Joaquın Cordero-Martınez (2023) Systems Biology in Reproductive Medicine 69(6):435–439. https://doi.org/10.1080/19396368.2023.2262714. The figure is located on the journal’s home page and the figure caption is: All polyamines induced a drastic decrease of sperm [cAMP]i under capacitation conditions compared to the control sample. Both KH7 and polyamines were positioned in the same pocket and the conformation adopted overlapped among by polyamines (gray and blue) while KH7 (colors) adopted more elongated structure due to its flexibility.

As in previous years, last year’s publications included papers co-authored by several of our Editorial Board members. These papers were two Reviews and Hypotheses – Oxidative versus reductive stress: a delicate balance for sperm integrity by Niloofar Sadeghi, Guylain Boissonneault, Marziyeh Tavalaee, and Mohammad Hossein Nasr-Esfahani https://doi.org/10.1080/19396368.2022.2119181; and Trophectoderm non-coding RNAs reflect the higher metabolic and more invasive properties of young maternal age blastocysts by Panagiotis Ntostis, Grace Swanson, Georgia Kokkali, David Iles, John Huntriss, Agni Pantou, Maria Tzetis, Konstantinos Pantos, Helen M. Picton, Stephen A. Krawetz and David Miller DOI: 10.1080/19396368.2022.2153636; a Research Communication – A transcriptomic insight into the human sperm microbiome through next-generation sequencing by Celia Corral-Vazquez, Joan Blanco, Riccardo Aiese Cigliano, Sarrate Zaida, Francesca Vidal and Ester Anton https://doi.org/10.1080/19396368.2023.2183912; and three Research Articles –The impact of cryopreservation on both sperm HPV-negative and positive subtypes by Maria Anagnostou, Maria Samara, Eleni Thodou, Christina I. Messini, Konstantinos Dafopoulos, Katerina Chatzimeletiou, Eleni Dovolou, Alexandros Daponte, George Koukoulis and George Anifandis https://doi.org/10.1080/19396368.2023.2198069; Exploring the internal exposome of seminal plasma with semen quality and live birth: A Pilot Study by Emily Houle, YuanYuan Li, Madison Schroder, Susan L McRitchie, Tayyab Rahil, Cynthia K Sites, Susan Jenkins Sumner and J. Richard Pilsner https://doi.org/10.1080/19396368.2023.2195964; and Relationship among seminal antigenicity, antioxidant status and metabolically active sperm from Holstein-Friesian (Bos taurus) bulls by Santhanahalli Siddalingappa Archana, Divakar Swathi, Laxman Ramya, Hulliyurdurga Shameeulla Heena, Balaganur Krishnappa, Bala Krishnan Binsila, Duraisamy Rajendran and Sellappan Selvaraju https://doi.org/10.1080/19396368.2023.2198070.

We look forward to the submissions for this coming year as we continue to publish original basic, translational, and clinical research as we witness advancements in the field that fall within the broad reach of the journal. To access articles published online, visit Systems Biology in Reproductive Medicine at www.tandfonline.com/toc/iaan20/current.

We thank our international scientific and medical communities for their ongoing support of the journal and we extend our appreciation to those who serve as reviewers for Systems Biology in Reproductive Medicine.

On behalf of SBiRM, best wishes for a healthy and successful year ahead.

Yours truly,

Stephen A. Krawetz, Ph.D., Editor-in-Chief

SBiRM: Systems Biology in Reproductive Medicine

Charlotte B. Failing Professor of Fetal Therapy and Diagnosis, Department of Obstetrics and Gynecology, Molecular Medicine and Genetics,

Wayne State University School of Medicine

[email protected]

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