Noscapine-Encapsulated Nanopolymers: A Novel Drug-Carrier System to Target the Tumor Cells

ABSTRACT

Nanotechnology involves manipulating the physical and chemical properties as well structures at the nanoscale, often involving dimensions that are just tiny fractions of the width of a human hair. Nanotechnology is being used as the basis for new and more effective drug delivery systems and is in early stage development as scaffolding in nerve regeneration research. Predictions for the future have great significance not only in encouraging nanotechnology research and development but also in determining a means of oversight.

Noscapine binds to tubulin and alters its conformation and assembly properties; interferes with microtubule dynamics; does not significantly change the microtubule polymer mass even at higher concentrations; arrests a variety of mammalian cells, including drug-resistant variants in mitosis, and targets them for apoptosis; and inhibits progression of tumors. These properties of noscapine encourage further in-depth research and development of its use in treating and reversing a variety of cancers by introducing a viable anticancer formulation of noscapine in the current scenario. Therefore, in the present review, we explain the importance of cyclodextrin and proteins being used to improve the therapeutic efficacy of noscapine. Preparation of nanospheres increases the aqueous solubility of noscapines and the potential of nanoparticles as effective drug delivery tools for noscapines to cure cancer.

KEYWORDS:

• noscapines
• cancer
• drug delivery system