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Food Additives & Contaminants: Part A Volume 30, 2013 - Issue 6: Residues of veterinary medicines in food – recent developments in detection and determination of residues: Proceedings of EuroResidues VII held in the Netherlands, May 14–16th 2012
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Original Articles

Development and validation of an LC-MS/MS method for the determination of six gestagens in kidney fats

Martina RejtharováÚSKVBL – Institute for State Control of Veterinary Biologicals and Medicaments, Brno, Czech RepublicCorrespondence[email protected]
&
Libor RejtharÚSKVBL – Institute for State Control of Veterinary Biologicals and Medicaments, Brno, Czech Republic
Pages 995-999 | Received 13 Sep 2012, Accepted 03 Mar 2013, Published online: 28 May 2013
 
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Abstract

A method for the determination of residues of six steroids with gestagenic action (altrenogest, medroxyprogesterone acetate, megestrol acetate, melengestrol acetate, acetoxyprogesterone and chlormadinone acetate) in animal fat tissue was developed. The procedure consists of methanol extraction, clean-up on an alumina column and LC-MS/MS measurement. The method has been validated according to Decision 2002/657/EC. Decision limits for all analytes were observed within the range from 0.3 to 1.7 ng g–1, and recoveries were between 80% and 105%. The method is robust and can be applied for both screening and confirmatory analyses in routine residue monitoring.

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